Knot-Tying Force During Suturing and Wound Healing in the Gastrointestinal Tract

Junya Oguma, Soji Ozawa, Yasuhide Morikawa, Toshiharu Furukawa, Yuukou Kitagawa, Masakazu Ueda, Masaki Kitajima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Objective data should be obtained to determine the most suitable knot-tying force for appropriate suturing during robotic surgery. The purpose of this study was to estimate the appropriate force by investigating the efficiency of wound healing in the gastrointestinal tract in dog models. Methods: We cut and sutured the stomach and jejunum of 12 beagles, using different magnitudes of knot-tying forces. The relationship between the knot-tying force and variations in the density of the microvessels and basic-fibroblast growth factor (bFGF)-positive cells were evaluated. Results: On the 7th postoperative day (POD) in the stomach, and the 7th and 11th POD in the jejunum, the density of the microvessels in the submucosa at the sites of cutting and ligation was higher for the knot-tying force of 1.5 N than for any other forces used. On the 4th and 7th POD in the stomach and 11th POD in the jejunum, the density of bFGF-positive cell in the mucosa was higher for the knot-tying force of 1.5 N than for any of the other forces used. Conclusions: By assessing the efficiency of wound healing, it was determined that the knot-tying force of 1.5 N may be the most appropriate for optimal wound healing in the gastrointestinal tract of the beagles.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalJournal of Surgical Research
Volume140
Issue number1
DOIs
Publication statusPublished - 2007 Jun 1

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Jejunum
Wound Healing
Gastrointestinal Tract
Stomach
Fibroblast Growth Factor 2
Microvessels
Robotics
Ligation
Mucous Membrane
Dogs

Keywords

  • a sense of touch
  • knot-tying force
  • robotic surgery
  • wound healing

ASJC Scopus subject areas

  • Surgery

Cite this

Knot-Tying Force During Suturing and Wound Healing in the Gastrointestinal Tract. / Oguma, Junya; Ozawa, Soji; Morikawa, Yasuhide; Furukawa, Toshiharu; Kitagawa, Yuukou; Ueda, Masakazu; Kitajima, Masaki.

In: Journal of Surgical Research, Vol. 140, No. 1, 01.06.2007, p. 129-134.

Research output: Contribution to journalArticle

Oguma, Junya ; Ozawa, Soji ; Morikawa, Yasuhide ; Furukawa, Toshiharu ; Kitagawa, Yuukou ; Ueda, Masakazu ; Kitajima, Masaki. / Knot-Tying Force During Suturing and Wound Healing in the Gastrointestinal Tract. In: Journal of Surgical Research. 2007 ; Vol. 140, No. 1. pp. 129-134.
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