Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity

Tadashi Yoshida, Maho Yamashita, Chihiro Horimai, Matsuhiko Hayashi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: The identification of novel molecular mechanisms for cardiac hypertrophy is of considerable interest.

Results: Cardiomyocyte-specific knockout of KLF4 enhanced-adrenoreceptor agonist-induced cardiac hypertrophy by modulating myocardin expression and activity.

Conclusion: KLF4 is a novel regulator of cardiac hypertrophy.

Significance: Control of KLF4 is a potential therapeutic target for cardiac hypertrophy.

Original languageEnglish
Pages (from-to)26107-26118
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
Publication statusPublished - 2014 Sep 19

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Cardiomegaly
Isoproterenol
Proteins
Cardiac Myocytes
myocardin
GKLF protein
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. / Yoshida, Tadashi; Yamashita, Maho; Horimai, Chihiro; Hayashi, Matsuhiko.

In: Journal of Biological Chemistry, Vol. 289, No. 38, 19.09.2014, p. 26107-26118.

Research output: Contribution to journalArticle

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