Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity

Tadashi Yoshida; Maho Yamashita; Chihiro Horimai; Matsuhiko Hayashi

doi:10.1074/jbc.M114.582809

Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity

Tadashi Yoshida, Maho Yamashita, Chihiro Horimai, Matsuhiko Hayashi

Apheresis and Dialysis Center

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Background: The identification of novel molecular mechanisms for cardiac hypertrophy is of considerable interest.

Results: Cardiomyocyte-specific knockout of KLF4 enhanced-adrenoreceptor agonist-induced cardiac hypertrophy by modulating myocardin expression and activity.

Conclusion: KLF4 is a novel regulator of cardiac hypertrophy.

Significance: Control of KLF4 is a potential therapeutic target for cardiac hypertrophy.

Original language	English
Pages (from-to)	26107-26118
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	38
DOIs	https://doi.org/10.1074/jbc.M114.582809
Publication status	Published - 2014 Sept 19

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.582809

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title = "Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity",

abstract = "Background: The identification of novel molecular mechanisms for cardiac hypertrophy is of considerable interest.Results: Cardiomyocyte-specific knockout of KLF4 enhanced-adrenoreceptor agonist-induced cardiac hypertrophy by modulating myocardin expression and activity.Conclusion: KLF4 is a novel regulator of cardiac hypertrophy.Significance: Control of KLF4 is a potential therapeutic target for cardiac hypertrophy.",

author = "Tadashi Yoshida and Maho Yamashita and Chihiro Horimai and Matsuhiko Hayashi",

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AU - Yamashita, Maho

AU - Horimai, Chihiro

AU - Hayashi, Matsuhiko

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Background: The identification of novel molecular mechanisms for cardiac hypertrophy is of considerable interest.Results: Cardiomyocyte-specific knockout of KLF4 enhanced-adrenoreceptor agonist-induced cardiac hypertrophy by modulating myocardin expression and activity.Conclusion: KLF4 is a novel regulator of cardiac hypertrophy.Significance: Control of KLF4 is a potential therapeutic target for cardiac hypertrophy.

AB - Background: The identification of novel molecular mechanisms for cardiac hypertrophy is of considerable interest.Results: Cardiomyocyte-specific knockout of KLF4 enhanced-adrenoreceptor agonist-induced cardiac hypertrophy by modulating myocardin expression and activity.Conclusion: KLF4 is a novel regulator of cardiac hypertrophy.Significance: Control of KLF4 is a potential therapeutic target for cardiac hypertrophy.

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Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity

Abstract

ASJC Scopus subject areas

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