Kurahamide, a cyclic depsipeptide analog of dolastatin 13 from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki, Shinpei Sumimoto, Osamu Ohno, Shoichiro Suda, Kiyotake Suenaga

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Kurahamide, a new dolastatin 13 analog, was isolated from a marine cyanobacterial assemblage, consisting mostly of Lyngbya sp. Its gross structure was elucidated by spectroscopic analysis, and the stereochemistries were assigned based on a chiral HPLC analysis of hydrolysis products. Kurahamide strongly inhibited elastase and chymotrypsin in vitro. In addition, kurahamide moderately inhibited the growth of human cancer cells, including HeLa and HL60 cells.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalBulletin of the Chemical Society of Japan
Volume87
Issue number5
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)

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