TY - JOUR
T1 - Kurahamide, a cyclic depsipeptide analog of dolastatin 13 from a marine cyanobacterial assemblage of Lyngbya sp.
AU - Iwasaki, Arihiro
AU - Sumimoto, Shinpei
AU - Ohno, Osamu
AU - Suda, Shoichiro
AU - Suenaga, Kiyotake
PY - 2014
Y1 - 2014
N2 - Kurahamide, a new dolastatin 13 analog, was isolated from a marine cyanobacterial assemblage, consisting mostly of Lyngbya sp. Its gross structure was elucidated by spectroscopic analysis, and the stereochemistries were assigned based on a chiral HPLC analysis of hydrolysis products. Kurahamide strongly inhibited elastase and chymotrypsin in vitro. In addition, kurahamide moderately inhibited the growth of human cancer cells, including HeLa and HL60 cells.
AB - Kurahamide, a new dolastatin 13 analog, was isolated from a marine cyanobacterial assemblage, consisting mostly of Lyngbya sp. Its gross structure was elucidated by spectroscopic analysis, and the stereochemistries were assigned based on a chiral HPLC analysis of hydrolysis products. Kurahamide strongly inhibited elastase and chymotrypsin in vitro. In addition, kurahamide moderately inhibited the growth of human cancer cells, including HeLa and HL60 cells.
UR - http://www.scopus.com/inward/record.url?scp=84901070195&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901070195&partnerID=8YFLogxK
U2 - 10.1246/bcsj.20140008
DO - 10.1246/bcsj.20140008
M3 - Article
AN - SCOPUS:84901070195
SN - 0009-2673
VL - 87
SP - 609
EP - 613
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 5
ER -
