Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

Kaori Ozaki, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

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1 Citation (Scopus)


Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC 50 values of 0.13 nM and 1.1 μM.

Original languageEnglish
Publication statusPublished - 2019 Jan 1



  • Caldora penicillata
  • Cyclic depsipeptide
  • Marine natural products
  • Serine protease inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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