Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

Kaori Ozaki, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

Research output: Contribution to journalArticle

Abstract

Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC 50 values of 0.13 nM and 1.1 μM.

Original languageEnglish
JournalTetrahedron
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Depsipeptides
Spectroscopic analysis
Pancreatic Elastase
Chymotrypsin
Cyanobacteria
Cytotoxicity
HeLa Cells
Peptide Hydrolases
Acids
3-amino-6-hydroxy-2-piperidone

Keywords

  • Caldora penicillata
  • Cyclic depsipeptide
  • Marine natural products
  • Serine protease inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata. / Ozaki, Kaori; Iwasaki, Arihiro; Suenaga, Kiyotake; Teruya, Toshiaki.

In: Tetrahedron, 01.01.2019.

Research output: Contribution to journalArticle

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