Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

Kaori Ozaki, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC50 values of 0.13 nM and 1.1 μM.

Original languageEnglish
Pages (from-to)3382-3386
Number of pages5
JournalTetrahedron
Volume75
Issue number25
DOIs
Publication statusPublished - 2019 Jun 21

Keywords

  • Caldora penicillata
  • Cyclic depsipeptide
  • Marine natural products
  • Serine protease inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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