La Dolce Vita of Neurexin: Synaptic Partnerships through Glycosaminoglycans

Kunimichi Suzuki, Michisuke Yuzaki

Research output: Contribution to journalShort survey

Abstract

Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins. Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins.

Original languageEnglish
Pages (from-to)1337-1338
Number of pages2
JournalCell
Volume174
Issue number6
DOIs
Publication statusPublished - 2018 Sep 6

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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