Laboratory and clinical studies of mom(9, 3″-di-o-acetyl midecamycin) in pediatric field

Ryochi Fujii, Tatsuhiko Shinozaki, Hidenori Meguro, Shintaro Hashira, Yoriko Koike, Masatoshi Takimoto, Jun ichi Oki, Hajime Yoshioka, Aiko Takase, Ichimei Nagamatsu, Ryuzo Aoyama, Yoshiki Kakizaki, Akira Ohnishi, Makoto Fujita, Kishiro Nagata, Yukio Izumi, Naoko Sugaya, Mami Nanba, Yuri Okimoto, Akira NakamuraItaru Terashima, Suzuko Uehara, Susumu Nakazawa, Hajime Sato, Kenji Shinno, Yuichi Hirama, Akira Narita, Shin ichi Nakazawa, Shujiro Tikaoka, Tatue Tazoe, Kohji Yanagisawa, Hiroki Hoshina, Haruo Ichihashi, Ukio Iwasaki, Satoshi Iwata, Takefumi Kanemitu, Keiji Jozaki, Haruki Haatori, Ryo Wakabayashi, Yoshifumi Kojima, Tadatoshi Kuratsuji, Keisuke Sunakawa, Tadao Oikawa, Mituru Oshano, Yasuo Ichihashi, Makoto Hori, Yoshiie Kurosu, Yoshikiyo Toyoda, Morimasa Sugita, Mikio Minamitani, Kei Hachimori, Itsuo Minamikawa, Masatoshi Suzuki, Naoichi Iwai, Akira Sasaki, Yoichi Taneda, Fumiko Mizokuchi, Haruhi Nakamura, Tadafumi Nishimura, Toshio Takashima, Kenji Hiromatsu, Kazuo Tabuki, Michio Takagi, Yutaka Kobayashi, Tsunekazu Haruta, Shigekazu Kuroki, Kanetsu Ohkura

Research output: Contribution to journalArticle

Abstract

The authors have carried out the laboratory and clinical studies of MOM and obtained the following results: 1. The sensitivities of S. aureus: 114 strains, S. pyogenes: 144 strains and S. pneumoniae'. 35 strains to MOM, MDM and EM were distributed widely. In particular, two peaks existed clearly in the distribution of sensitivities to EM. The sensitivity of the superior peak of these two was higher by one to three tubes than the peak of MOM in three species. However, the frequency of the resistant strains to EM was the highest among these three drugs. The sensitivities of B. pertussis: nine strains to these drugs were below 0. 39 μg/ml and those to EM were the highest. The sensitivities of H. influenzae: 12 strains to MOM and MDM were above 12. 5μg/ml. 2. The serum concentrations and urinary excretion rate of MOM dry syrup were measured in 22 pediatric patients by oral administration at the dose of 10 mg/kg and in 24 patients at the dose of 20 mg/kg. The peak of mean serum concentrations of MOM for the 10 mg/kg group and the 20 mg/kg group were 0.756 μg/ml and 1. 010 μg/ml respectively at one hour after administration. The mean urinary recovery rates of MOM for the former group and for the latter were 1.67% and 2.46% respectively for six hours after administration. 3. The clinical responses of MOM were excellent in 53 cases, good in 174, fair in 28 and poor in 45 out of 300 cases, i. e. 39 cases with pharyngitis, 57 with tonsillitis, 35 with bronchitis, 17 with pneumonia, 79 with mycoplasmal respiratory tract infection, 45 with scarlet fever, 26 with whooping cough, one with S. S. S. S. and one with otitis media. Overall efficacy rate was 75. 7%. The difference in the efficacy rate was not statistically significant when the clinical response was compared among groups of four different daily dose, i.e. below 20 mg/kg, 21∼30 mg/kg, 31∼40 mg/kg and above 41 mg/kg. Fifty-eitht out of 117 strains isolated were eradicated. The clinical side effects of MOM in 378 cases (including dropout cases) were observed in 14 cases (3. 70%), i. e. four cases of exanthema and 10 cases of gastrointestinal abnormality like diarrhea. No severe side effects like hepatitis were observed. As to the clinical laboratory findings of MOM, a slight elevation of GOT in three cases, GPT in two cases, GOT-GPT-total bilirubin in one case and the eosinophilia in four cases were observed, but these were mild.

Original languageEnglish
Pages (from-to)53-66
Number of pages14
JournalChemotherapy
Volume31
Issue number1
DOIs
Publication statusPublished - 1983

    Fingerprint

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Fujii, R., Shinozaki, T., Meguro, H., Hashira, S., Koike, Y., Takimoto, M., Oki, J. I., Yoshioka, H., Takase, A., Nagamatsu, I., Aoyama, R., Kakizaki, Y., Ohnishi, A., Fujita, M., Nagata, K., Izumi, Y., Sugaya, N., Nanba, M., Okimoto, Y., ... Ohkura, K. (1983). Laboratory and clinical studies of mom(9, 3″-di-o-acetyl midecamycin) in pediatric field. Chemotherapy, 31(1), 53-66. https://doi.org/10.11250/chemotherapy1953.31.53