Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Yohei Takahashi, Morio Matsumoto, Tatsuki Karasugi, Koota Watanabe, Kazuhiro Chiba, Noriaki Kawakami, Taichi Tsuji, Koki Uno, Teppei Suzuki, Manabu Ito, Hideki Sudo, Shohei Minami, Toshiaki Kotani, Katsuki Kono, Haruhisa Yanagida, Hiroshi Taneichi, Atsushi Takahashi, Yoshiaki Toyama, Shiro Ikegawa

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalJournal of Orthopaedic Research
Volume29
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Fingerprint

Matrilin Proteins
Melatonin MT2 Receptor
Tryptophan Hydroxylase
Scoliosis
Somatomedins
Single Nucleotide Polymorphism
Population
Genetic Predisposition to Disease
Puberty
Sample Size

Keywords

  • adolescent idiopathic scoliosis
  • association
  • curve severity
  • predisposition

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. / Takahashi, Yohei; Matsumoto, Morio; Karasugi, Tatsuki; Watanabe, Koota; Chiba, Kazuhiro; Kawakami, Noriaki; Tsuji, Taichi; Uno, Koki; Suzuki, Teppei; Ito, Manabu; Sudo, Hideki; Minami, Shohei; Kotani, Toshiaki; Kono, Katsuki; Yanagida, Haruhisa; Taneichi, Hiroshi; Takahashi, Atsushi; Toyama, Yoshiaki; Ikegawa, Shiro.

In: Journal of Orthopaedic Research, Vol. 29, No. 7, 07.2011, p. 1055-1058.

Research output: Contribution to journalArticle

Takahashi, Y, Matsumoto, M, Karasugi, T, Watanabe, K, Chiba, K, Kawakami, N, Tsuji, T, Uno, K, Suzuki, T, Ito, M, Sudo, H, Minami, S, Kotani, T, Kono, K, Yanagida, H, Taneichi, H, Takahashi, A, Toyama, Y & Ikegawa, S 2011, 'Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population', Journal of Orthopaedic Research, vol. 29, no. 7, pp. 1055-1058. https://doi.org/10.1002/jor.21347
Takahashi, Yohei ; Matsumoto, Morio ; Karasugi, Tatsuki ; Watanabe, Koota ; Chiba, Kazuhiro ; Kawakami, Noriaki ; Tsuji, Taichi ; Uno, Koki ; Suzuki, Teppei ; Ito, Manabu ; Sudo, Hideki ; Minami, Shohei ; Kotani, Toshiaki ; Kono, Katsuki ; Yanagida, Haruhisa ; Taneichi, Hiroshi ; Takahashi, Atsushi ; Toyama, Yoshiaki ; Ikegawa, Shiro. / Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. In: Journal of Orthopaedic Research. 2011 ; Vol. 29, No. 7. pp. 1055-1058.
@article{94546482be2c42cab251edb48a87b6d9,
title = "Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population",
abstract = "Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.",
keywords = "adolescent idiopathic scoliosis, association, curve severity, predisposition",
author = "Yohei Takahashi and Morio Matsumoto and Tatsuki Karasugi and Koota Watanabe and Kazuhiro Chiba and Noriaki Kawakami and Taichi Tsuji and Koki Uno and Teppei Suzuki and Manabu Ito and Hideki Sudo and Shohei Minami and Toshiaki Kotani and Katsuki Kono and Haruhisa Yanagida and Hiroshi Taneichi and Atsushi Takahashi and Yoshiaki Toyama and Shiro Ikegawa",
year = "2011",
month = "7",
doi = "10.1002/jor.21347",
language = "English",
volume = "29",
pages = "1055--1058",
journal = "Journal of Orthopaedic Research",
issn = "0736-0266",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

AU - Takahashi, Yohei

AU - Matsumoto, Morio

AU - Karasugi, Tatsuki

AU - Watanabe, Koota

AU - Chiba, Kazuhiro

AU - Kawakami, Noriaki

AU - Tsuji, Taichi

AU - Uno, Koki

AU - Suzuki, Teppei

AU - Ito, Manabu

AU - Sudo, Hideki

AU - Minami, Shohei

AU - Kotani, Toshiaki

AU - Kono, Katsuki

AU - Yanagida, Haruhisa

AU - Taneichi, Hiroshi

AU - Takahashi, Atsushi

AU - Toyama, Yoshiaki

AU - Ikegawa, Shiro

PY - 2011/7

Y1 - 2011/7

N2 - Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.

AB - Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.

KW - adolescent idiopathic scoliosis

KW - association

KW - curve severity

KW - predisposition

UR - http://www.scopus.com/inward/record.url?scp=79955893036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955893036&partnerID=8YFLogxK

U2 - 10.1002/jor.21347

DO - 10.1002/jor.21347

M3 - Article

VL - 29

SP - 1055

EP - 1058

JO - Journal of Orthopaedic Research

JF - Journal of Orthopaedic Research

SN - 0736-0266

IS - 7

ER -