Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users

Shigeru Nakamura, Shigeru Kinoshita, Norihiko Yokoi, Yoko Ogawa, Michiko Shibuya, Hideo Nakashima, Ryuji Hisamura, Toshihiro Imada, Tomohiro Imagawa, Masato Uehara, Izumi Shibuya, Murat Dogru, Samantha Ward, Kazuo Tsubota

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: Dry eye has shown a marked increase due to visual display terminal (VDT) use. It remains unclear whether reduced blinking while focusing can have a direct deleterious impact on the lacrimal gland function. To address this issue that potentially affects the life quality, we conducted a large-scale epidemiological study of VDT users and an animal study. Methodology/Principal Findings: Cross sectional survey carried out in Japan. A total of 1025 office workers who use VDT were enrolled. The association between VDT work duration and changes in tear film status, precorneal tear stability, lipid layer status and tear secretion were analyzed. For the animal model study, the rat VDT user model, placing rats onto a balance swing in combination with exposure to an evaporative environment was used to analyze lacrimal gland function. There was no positive relationship between VDT working duration and change in tear film stability and lipid layer status. The odds ratio for decrease in Schirmer score, index of tear secretion, were significantly increased with VDT working year (P = 0.012) and time (P = 0.005). The rat VDT user model, showed chronic reduction of tear secretion and was accompanied by an impairment of the lacrimal gland function and morphology. This dysfunction was recovered when rats were moved to resting conditions without the swing. Conclusions/Significance: These data suggest that lacrimal gland hypofunction is associated with VDT use and may be a critical mechanism for VDT-associated dry eye. We believe this to be the first mechanistic link to the pathogenesis of dry eye in office workers.

Original languageEnglish
Article numbere11119
JournalPLoS One
Volume5
Issue number6
DOIs
Publication statusPublished - 2010

Fingerprint

Tears
lacrimal apparatus
Lacrimal Apparatus
eyes
Display devices
secretion
Rats
rats
animal models
Lipids
Blinking
duration
lipids
quality of life
Animals
cross-sectional studies
odds ratio
epidemiological studies
Epidemiologic Studies
Japan

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Nakamura, S., Kinoshita, S., Yokoi, N., Ogawa, Y., Shibuya, M., Nakashima, H., ... Tsubota, K. (2010). Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS One, 5(6), [e11119]. https://doi.org/10.1371/journal.pone.0011119

Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. / Nakamura, Shigeru; Kinoshita, Shigeru; Yokoi, Norihiko; Ogawa, Yoko; Shibuya, Michiko; Nakashima, Hideo; Hisamura, Ryuji; Imada, Toshihiro; Imagawa, Tomohiro; Uehara, Masato; Shibuya, Izumi; Dogru, Murat; Ward, Samantha; Tsubota, Kazuo.

In: PLoS One, Vol. 5, No. 6, e11119, 2010.

Research output: Contribution to journalArticle

Nakamura, S, Kinoshita, S, Yokoi, N, Ogawa, Y, Shibuya, M, Nakashima, H, Hisamura, R, Imada, T, Imagawa, T, Uehara, M, Shibuya, I, Dogru, M, Ward, S & Tsubota, K 2010, 'Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users', PLoS One, vol. 5, no. 6, e11119. https://doi.org/10.1371/journal.pone.0011119
Nakamura S, Kinoshita S, Yokoi N, Ogawa Y, Shibuya M, Nakashima H et al. Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS One. 2010;5(6). e11119. https://doi.org/10.1371/journal.pone.0011119
Nakamura, Shigeru ; Kinoshita, Shigeru ; Yokoi, Norihiko ; Ogawa, Yoko ; Shibuya, Michiko ; Nakashima, Hideo ; Hisamura, Ryuji ; Imada, Toshihiro ; Imagawa, Tomohiro ; Uehara, Masato ; Shibuya, Izumi ; Dogru, Murat ; Ward, Samantha ; Tsubota, Kazuo. / Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. In: PLoS One. 2010 ; Vol. 5, No. 6.
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