Lactation and risk of endometrial cancer in Japan

A case-control study

Chikako Okamura, Yoshitaka Tsubono, Kiyoshi Ito, Hitoshi Niikura, Tadao Takano, Satoru Nagase, Kohsuke Yoshinaga, Yukihiro Terada, Takashi Murakami, Shinji Sato, Daisuke Aoki, Toshiko Jobo, Kunihiro Okamura, Nobuo Yaegashi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The incidence of endometrial cancer is rapidly increasing in Japan. Although the risk factors in European populations have been well described, there are few epidemiologic studies regarding risk factors for endometrial cancer in Japanese women. This hospital-based case-control study among Japanese women was carried out from 1998 to 2000. The cases were selected from women with endometrial cancer (n = 155), and the controls selected from women attending the university gynecological outpatient clinic for cervical cancer screening (n = 96). Subjects were interviewed to ascertain breast feeding practices, contraceptive usage, as well as potential risk factors for endometrial cancer. We observed a lower risk of endometrial cancer associated with oral contraceptive (OC) and a higher risk associated with higher body mass index (BMI), and older ages at first and last delivery. Gravidity reduced odds ratio (OR) for endometerial cancer to 0.34 (95% confidence interval [CI] 0.13-0.92). Compared with parous women who had never breastfed, the multivariate OR for women with a history of breastfeeding was 0.37 (95% CI, 0.17-0.82). Additionally, a greater lapse of time since breastfeeding increased OR for endometrial cancer by over three times. In conclusion, the present study has indicated that breastfeeding reduces the risk of endometrial cancer in Japanese women.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalTohoku Journal of Experimental Medicine
Volume208
Issue number2
DOIs
Publication statusPublished - 2006 Jan 25

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Endometrial Neoplasms
Lactation
Case-Control Studies
Japan
Breast Feeding
Odds Ratio
Contraception Behavior
Confidence Intervals
Gravidity
Oral Contraceptives
Contraceptive Agents
Ambulatory Care Facilities
Early Detection of Cancer
Screening
Uterine Cervical Neoplasms
Epidemiologic Studies
Body Mass Index
Incidence
Population
Neoplasms

Keywords

  • Breastfeeding
  • Case-control study
  • Endometrial cancer
  • Risk factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Okamura, C., Tsubono, Y., Ito, K., Niikura, H., Takano, T., Nagase, S., ... Yaegashi, N. (2006). Lactation and risk of endometrial cancer in Japan: A case-control study. Tohoku Journal of Experimental Medicine, 208(2), 109-115. https://doi.org/10.1620/tjem.208.109

Lactation and risk of endometrial cancer in Japan : A case-control study. / Okamura, Chikako; Tsubono, Yoshitaka; Ito, Kiyoshi; Niikura, Hitoshi; Takano, Tadao; Nagase, Satoru; Yoshinaga, Kohsuke; Terada, Yukihiro; Murakami, Takashi; Sato, Shinji; Aoki, Daisuke; Jobo, Toshiko; Okamura, Kunihiro; Yaegashi, Nobuo.

In: Tohoku Journal of Experimental Medicine, Vol. 208, No. 2, 25.01.2006, p. 109-115.

Research output: Contribution to journalArticle

Okamura, C, Tsubono, Y, Ito, K, Niikura, H, Takano, T, Nagase, S, Yoshinaga, K, Terada, Y, Murakami, T, Sato, S, Aoki, D, Jobo, T, Okamura, K & Yaegashi, N 2006, 'Lactation and risk of endometrial cancer in Japan: A case-control study', Tohoku Journal of Experimental Medicine, vol. 208, no. 2, pp. 109-115. https://doi.org/10.1620/tjem.208.109
Okamura C, Tsubono Y, Ito K, Niikura H, Takano T, Nagase S et al. Lactation and risk of endometrial cancer in Japan: A case-control study. Tohoku Journal of Experimental Medicine. 2006 Jan 25;208(2):109-115. https://doi.org/10.1620/tjem.208.109
Okamura, Chikako ; Tsubono, Yoshitaka ; Ito, Kiyoshi ; Niikura, Hitoshi ; Takano, Tadao ; Nagase, Satoru ; Yoshinaga, Kohsuke ; Terada, Yukihiro ; Murakami, Takashi ; Sato, Shinji ; Aoki, Daisuke ; Jobo, Toshiko ; Okamura, Kunihiro ; Yaegashi, Nobuo. / Lactation and risk of endometrial cancer in Japan : A case-control study. In: Tohoku Journal of Experimental Medicine. 2006 ; Vol. 208, No. 2. pp. 109-115.
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