Lactoferrin in gastrointestinal disease

Tetsuo Hayakawa, Chun Xiang Jin, Shigeru Ko, Motoji Kitagawa, Hiroshi Ishiguro

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Lactoferrin, a major whey protein, is a red iron-binding protein present mainly in external secretions such as breast milk and in polymorphonuclear neutrophils. The presence of lactoferrin in body fluids is proportional to the flux of neutrophils and its assessment can provide a reliable biomarker for inflammation. In gastrointestinal diseases increased fecal lactoferrin is a sensitive and specific surrogate marker for inflammatory bowel diseases in patients with chronic diarrhea and pain, and ascites lactoferrin can also provide a promising and reliable biomarker for bacterial peritonitis. Lactoferrin in pancreatic juice and stone could provide pathophysiological information of protein plug and stone formation in the pancreatic duct. Serum antilactoferrin autoantibody might contribute to the clarification of the pathogenetic mechanisms of autoimmune pancreatitis and liver diseases, although its diagnostic and prognostic value appears to be limited. Further studies will be necessary to elucidate the exact details.

Original languageEnglish
Pages (from-to)1251-1254
Number of pages4
JournalInternal Medicine
Volume48
Issue number15
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Lactoferrin
Gastrointestinal Diseases
Biomarkers
Neutrophils
Iron-Binding Proteins
Pancreatic Juice
Pancreatic Ducts
Body Fluids
Human Milk
Peritonitis
Inflammatory Bowel Diseases
Ascites
Chronic Pain
Pancreatitis
Autoantibodies
Autoimmune Diseases
Liver Diseases
Diarrhea
Inflammation
Serum

Keywords

  • Anti-lactoferrin antibody
  • Autoimmune liver disease
  • Autoimmune pancreatitis
  • Chronic pancreatitis
  • Iinflammatory bowel disease
  • Lactoferrin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hayakawa, T., Jin, C. X., Ko, S., Kitagawa, M., & Ishiguro, H. (2009). Lactoferrin in gastrointestinal disease. Internal Medicine, 48(15), 1251-1254. https://doi.org/10.2169/internalmedicine.48.2199

Lactoferrin in gastrointestinal disease. / Hayakawa, Tetsuo; Jin, Chun Xiang; Ko, Shigeru; Kitagawa, Motoji; Ishiguro, Hiroshi.

In: Internal Medicine, Vol. 48, No. 15, 2009, p. 1251-1254.

Research output: Contribution to journalArticle

Hayakawa, T, Jin, CX, Ko, S, Kitagawa, M & Ishiguro, H 2009, 'Lactoferrin in gastrointestinal disease', Internal Medicine, vol. 48, no. 15, pp. 1251-1254. https://doi.org/10.2169/internalmedicine.48.2199
Hayakawa, Tetsuo ; Jin, Chun Xiang ; Ko, Shigeru ; Kitagawa, Motoji ; Ishiguro, Hiroshi. / Lactoferrin in gastrointestinal disease. In: Internal Medicine. 2009 ; Vol. 48, No. 15. pp. 1251-1254.
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