Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study

Megumi Tsubota-Utsugi, Michihiro Satoh, Naoki Tomita, Azusa Hara, Takeo Kondo, Miki Hosaka, Sho Saito, Kei Asayama, Ryusuke Inoue, Mikio Hirano, Aya Hosokawa, Keiko Murakami, Takahisa Murakami, Hirohito Metoki, Masahiro Kikuya, Shin Ichi Izumi, Yutaka Imai, Takayoshi Ohkubo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective We aimed to determine the associations between silent cerebrovascular lesions, characterized by lacunar infarcts and white matter hyperintensity, and future decline in higher level functional capacity in older community-dwelling adults. Materials and Methods For this observational study, we selected individuals from the general population of Ohasama, a rural Japanese community. Three hundred thirty-one participants who were free of functional decline at baseline and who were at least 60 years old underwent brain magnetic resonance imaging and answered a questionnaire on higher level functional capacity derived from the Tokyo Metropolitan Institute of Gerontology Index of Competence. Weassessed the relationship between silent cerebrovascular lesions with a decline in higher level functional capacity at 7 years using multiple logistic regression analysis adjusted for possible confounding factors. Results During the follow-up, 22.1% reported declines in higher level functional capacity. After adjustment for putative confounding factors, the presence of silent cerebrovascular lesions (odds ratio [95% confidence interval], 2.10 [1.05-4.21]) and both lacunar infarcts (2.04 [1.05-3.95]) and white matter hyperintensity (2.02 [1.02-3.95]) was significantly associated with the risk of functional decline at 7-year follow-up. In subscale analysis, specifically lacunar infarcts were strongly associated with the future risk of decline in intellectual activity (3.16 [1.27-7.84]). Conclusion Silent cerebrovascular lesions are associated with future risk of decline in higher level functional capacity. Appropriate management of health risk factors to prevent silent cerebrovascular lesions may prevent higher level functional decline in the elderly population.

Original languageEnglish
Pages (from-to)376-384
Number of pages9
JournalJournal of Stroke and Cerebrovascular Diseases
Volume26
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1
Externally publishedYes

Fingerprint

Lacunar Stroke
Independent Living
Tokyo
Rural Population
Geriatrics
Mental Competency
Population
Observational Studies
Logistic Models
Odds Ratio
Regression Analysis
Magnetic Resonance Imaging
Confidence Intervals
Health
Brain
White Matter

Keywords

  • elderly
  • Functional capacity in early stage
  • Japanese
  • lacunar infarcts
  • silent cerebrovascular lesions
  • white matter hyperintensity

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline : The Ohasama Study. / Tsubota-Utsugi, Megumi; Satoh, Michihiro; Tomita, Naoki; Hara, Azusa; Kondo, Takeo; Hosaka, Miki; Saito, Sho; Asayama, Kei; Inoue, Ryusuke; Hirano, Mikio; Hosokawa, Aya; Murakami, Keiko; Murakami, Takahisa; Metoki, Hirohito; Kikuya, Masahiro; Izumi, Shin Ichi; Imai, Yutaka; Ohkubo, Takayoshi.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 26, No. 2, 01.02.2017, p. 376-384.

Research output: Contribution to journalArticle

Tsubota-Utsugi, M, Satoh, M, Tomita, N, Hara, A, Kondo, T, Hosaka, M, Saito, S, Asayama, K, Inoue, R, Hirano, M, Hosokawa, A, Murakami, K, Murakami, T, Metoki, H, Kikuya, M, Izumi, SI, Imai, Y & Ohkubo, T 2017, 'Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study', Journal of Stroke and Cerebrovascular Diseases, vol. 26, no. 2, pp. 376-384. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.09.036
Tsubota-Utsugi, Megumi ; Satoh, Michihiro ; Tomita, Naoki ; Hara, Azusa ; Kondo, Takeo ; Hosaka, Miki ; Saito, Sho ; Asayama, Kei ; Inoue, Ryusuke ; Hirano, Mikio ; Hosokawa, Aya ; Murakami, Keiko ; Murakami, Takahisa ; Metoki, Hirohito ; Kikuya, Masahiro ; Izumi, Shin Ichi ; Imai, Yutaka ; Ohkubo, Takayoshi. / Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline : The Ohasama Study. In: Journal of Stroke and Cerebrovascular Diseases. 2017 ; Vol. 26, No. 2. pp. 376-384.
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AU - Satoh, Michihiro

AU - Tomita, Naoki

AU - Hara, Azusa

AU - Kondo, Takeo

AU - Hosaka, Miki

AU - Saito, Sho

AU - Asayama, Kei

AU - Inoue, Ryusuke

AU - Hirano, Mikio

AU - Hosokawa, Aya

AU - Murakami, Keiko

AU - Murakami, Takahisa

AU - Metoki, Hirohito

AU - Kikuya, Masahiro

AU - Izumi, Shin Ichi

AU - Imai, Yutaka

AU - Ohkubo, Takayoshi

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N2 - Objective We aimed to determine the associations between silent cerebrovascular lesions, characterized by lacunar infarcts and white matter hyperintensity, and future decline in higher level functional capacity in older community-dwelling adults. Materials and Methods For this observational study, we selected individuals from the general population of Ohasama, a rural Japanese community. Three hundred thirty-one participants who were free of functional decline at baseline and who were at least 60 years old underwent brain magnetic resonance imaging and answered a questionnaire on higher level functional capacity derived from the Tokyo Metropolitan Institute of Gerontology Index of Competence. Weassessed the relationship between silent cerebrovascular lesions with a decline in higher level functional capacity at 7 years using multiple logistic regression analysis adjusted for possible confounding factors. Results During the follow-up, 22.1% reported declines in higher level functional capacity. After adjustment for putative confounding factors, the presence of silent cerebrovascular lesions (odds ratio [95% confidence interval], 2.10 [1.05-4.21]) and both lacunar infarcts (2.04 [1.05-3.95]) and white matter hyperintensity (2.02 [1.02-3.95]) was significantly associated with the risk of functional decline at 7-year follow-up. In subscale analysis, specifically lacunar infarcts were strongly associated with the future risk of decline in intellectual activity (3.16 [1.27-7.84]). Conclusion Silent cerebrovascular lesions are associated with future risk of decline in higher level functional capacity. Appropriate management of health risk factors to prevent silent cerebrovascular lesions may prevent higher level functional decline in the elderly population.

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