Lansoprazole for maintenance therapy of peptic ulcer disease: Weekend full-dose or everyday half-dose administration?

E. Hoshino, N. Umeda, J. Sano, K. Miki, Naohisa Yahagi, M. Oka, M. Kimura, H. Miyashita

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Seventy one patients with peptic ulcer (44 gastric ulcer and 27 duodenal ulcer patients) were enrolled in this study. After the ulcers had healed with 2 months of treatment with lansoprazole (LPZ) 30 mg/day, patients were divided into two groups: 43 in the half-dose q.d. group and 28 in the weekend full-dose group. Fourteen (23%) of the 43 patients in the half-dose q.d. group and 14 of the 28 (50%) in the weekend full-dose group failed to continue taking the drug for 6 months owing to poor compliance (p < 0.05). None of the 30 patients who continued to take the maintenance dose of LPZ experienced ulcer recurrence during the 6-month follow-up period, whereas 71% of the patients who stopped taking LPZ experienced recurrence (p < 0.01). In conclusion, maintenance therapy using the half-dose q.d. administration schedule was superior to weekend full-dose administration because of the better patient compliance and a lower ulcer recurrence rate.

Original languageEnglish
JournalJournal of Clinical Gastroenterology
Issue numberSUPPL. 2
Publication statusPublished - 1995
Externally publishedYes



  • Duodenal ulcer
  • Gastric ulcer
  • Lansoprazole
  • Maintenance therapy
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Gastroenterology

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