Lansoprazole for maintenance therapy of peptic ulcer disease: Weekend full-dose or everyday half-dose administration?

E. Hoshino, N. Umeda, J. Sano, K. Miki, Naohisa Yahagi, M. Oka, M. Kimura, H. Miyashita

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seventy one patients with peptic ulcer (44 gastric ulcer and 27 duodenal ulcer patients) were enrolled in this study. After the ulcers had healed with 2 months of treatment with lansoprazole (LPZ) 30 mg/day, patients were divided into two groups: 43 in the half-dose q.d. group and 28 in the weekend full-dose group. Fourteen (23%) of the 43 patients in the half-dose q.d. group and 14 of the 28 (50%) in the weekend full-dose group failed to continue taking the drug for 6 months owing to poor compliance (p < 0.05). None of the 30 patients who continued to take the maintenance dose of LPZ experienced ulcer recurrence during the 6-month follow-up period, whereas 71% of the patients who stopped taking LPZ experienced recurrence (p < 0.01). In conclusion, maintenance therapy using the half-dose q.d. administration schedule was superior to weekend full-dose administration because of the better patient compliance and a lower ulcer recurrence rate.

Original languageEnglish
JournalJournal of Clinical Gastroenterology
Volume20
Issue numberSUPPL. 2
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Lansoprazole
Peptic Ulcer
Ulcer
Recurrence
Therapeutics
Stomach Ulcer
Patient Compliance
Duodenal Ulcer
Appointments and Schedules
Pharmaceutical Preparations

Keywords

  • Duodenal ulcer
  • Gastric ulcer
  • Lansoprazole
  • Maintenance therapy
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lansoprazole for maintenance therapy of peptic ulcer disease : Weekend full-dose or everyday half-dose administration? / Hoshino, E.; Umeda, N.; Sano, J.; Miki, K.; Yahagi, Naohisa; Oka, M.; Kimura, M.; Miyashita, H.

In: Journal of Clinical Gastroenterology, Vol. 20, No. SUPPL. 2, 1995.

Research output: Contribution to journalArticle

Hoshino, E. ; Umeda, N. ; Sano, J. ; Miki, K. ; Yahagi, Naohisa ; Oka, M. ; Kimura, M. ; Miyashita, H. / Lansoprazole for maintenance therapy of peptic ulcer disease : Weekend full-dose or everyday half-dose administration?. In: Journal of Clinical Gastroenterology. 1995 ; Vol. 20, No. SUPPL. 2.
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AU - Miki, K.

AU - Yahagi, Naohisa

AU - Oka, M.

AU - Kimura, M.

AU - Miyashita, H.

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