Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer

A novel and minimally invasive approach

Yuukou Kitagawa, M. Ohgami, H. Fujii, M. Mukai, T. Kubota, N. Ando, M. Watanabe, Y. Otani, S. Ozawa, H. Hasegawa, Toshiharu Furukawa, J. I. Matsuda, K. Kumai, T. Ikeda, A. Kubo, M. Kitajima

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Although the sentinel node (SN) concept has been validated in malignant melanoma and breast cancer, the application of this concept for other solid tumors, including gastrointestinal (GI) cancer, is still controversial. We have demonstrated the feasibility of radioguided SN mapping during laparotomy in patients with esophageal, gastric, and colorectal cancers. In 188 patients, the SNs identified by this technique had an overall diagnostic accuracy of 96% for regional lymph node metastasis. Aberrant drainage sites that have been called skip metastasis from the primary lesion were detectable using this method. More recently, we have undertaken SN mapping during laparoscopic surgery. A combination of radiotracer and blue dye optimized the identification of SNs that drained GI cancers. Our preliminary data indicate that laparoscopic mapping of the SN is a sensitive intraoperative technique for identifying lymph node micrometastasis, and we believe that it will become an important component of a minimally invasive approach to early-stage GI cancers.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalAnnals of Surgical Oncology
Volume8
Issue number9 SUPPL.
Publication statusPublished - 2001

Fingerprint

Gastrointestinal Neoplasms
Lymph Nodes
Neoplasm Metastasis
Neoplasm Micrometastasis
Esophageal Neoplasms
Laparoscopy
Laparotomy
Stomach Neoplasms
Drainage
Colorectal Neoplasms
Melanoma
Coloring Agents
Breast Neoplasms
Sentinel Lymph Node
cyhalothrin
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Kitagawa, Y., Ohgami, M., Fujii, H., Mukai, M., Kubota, T., Ando, N., ... Kitajima, M. (2001). Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: A novel and minimally invasive approach. Annals of Surgical Oncology, 8(9 SUPPL.), 86-89.

Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer : A novel and minimally invasive approach. / Kitagawa, Yuukou; Ohgami, M.; Fujii, H.; Mukai, M.; Kubota, T.; Ando, N.; Watanabe, M.; Otani, Y.; Ozawa, S.; Hasegawa, H.; Furukawa, Toshiharu; Matsuda, J. I.; Kumai, K.; Ikeda, T.; Kubo, A.; Kitajima, M.

In: Annals of Surgical Oncology, Vol. 8, No. 9 SUPPL., 2001, p. 86-89.

Research output: Contribution to journalArticle

Kitagawa, Y, Ohgami, M, Fujii, H, Mukai, M, Kubota, T, Ando, N, Watanabe, M, Otani, Y, Ozawa, S, Hasegawa, H, Furukawa, T, Matsuda, JI, Kumai, K, Ikeda, T, Kubo, A & Kitajima, M 2001, 'Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: A novel and minimally invasive approach', Annals of Surgical Oncology, vol. 8, no. 9 SUPPL., pp. 86-89.
Kitagawa, Yuukou ; Ohgami, M. ; Fujii, H. ; Mukai, M. ; Kubota, T. ; Ando, N. ; Watanabe, M. ; Otani, Y. ; Ozawa, S. ; Hasegawa, H. ; Furukawa, Toshiharu ; Matsuda, J. I. ; Kumai, K. ; Ikeda, T. ; Kubo, A. ; Kitajima, M. / Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer : A novel and minimally invasive approach. In: Annals of Surgical Oncology. 2001 ; Vol. 8, No. 9 SUPPL. pp. 86-89.
@article{4240d3a2721f42bbbc5c0d6f2aa3f41d,
title = "Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer: A novel and minimally invasive approach",
abstract = "Although the sentinel node (SN) concept has been validated in malignant melanoma and breast cancer, the application of this concept for other solid tumors, including gastrointestinal (GI) cancer, is still controversial. We have demonstrated the feasibility of radioguided SN mapping during laparotomy in patients with esophageal, gastric, and colorectal cancers. In 188 patients, the SNs identified by this technique had an overall diagnostic accuracy of 96{\%} for regional lymph node metastasis. Aberrant drainage sites that have been called skip metastasis from the primary lesion were detectable using this method. More recently, we have undertaken SN mapping during laparoscopic surgery. A combination of radiotracer and blue dye optimized the identification of SNs that drained GI cancers. Our preliminary data indicate that laparoscopic mapping of the SN is a sensitive intraoperative technique for identifying lymph node micrometastasis, and we believe that it will become an important component of a minimally invasive approach to early-stage GI cancers.",
author = "Yuukou Kitagawa and M. Ohgami and H. Fujii and M. Mukai and T. Kubota and N. Ando and M. Watanabe and Y. Otani and S. Ozawa and H. Hasegawa and Toshiharu Furukawa and Matsuda, {J. I.} and K. Kumai and T. Ikeda and A. Kubo and M. Kitajima",
year = "2001",
language = "English",
volume = "8",
pages = "86--89",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "9 SUPPL.",

}

TY - JOUR

T1 - Laparoscopic detection of sentinel lymph nodes in gastrointestinal cancer

T2 - A novel and minimally invasive approach

AU - Kitagawa, Yuukou

AU - Ohgami, M.

AU - Fujii, H.

AU - Mukai, M.

AU - Kubota, T.

AU - Ando, N.

AU - Watanabe, M.

AU - Otani, Y.

AU - Ozawa, S.

AU - Hasegawa, H.

AU - Furukawa, Toshiharu

AU - Matsuda, J. I.

AU - Kumai, K.

AU - Ikeda, T.

AU - Kubo, A.

AU - Kitajima, M.

PY - 2001

Y1 - 2001

N2 - Although the sentinel node (SN) concept has been validated in malignant melanoma and breast cancer, the application of this concept for other solid tumors, including gastrointestinal (GI) cancer, is still controversial. We have demonstrated the feasibility of radioguided SN mapping during laparotomy in patients with esophageal, gastric, and colorectal cancers. In 188 patients, the SNs identified by this technique had an overall diagnostic accuracy of 96% for regional lymph node metastasis. Aberrant drainage sites that have been called skip metastasis from the primary lesion were detectable using this method. More recently, we have undertaken SN mapping during laparoscopic surgery. A combination of radiotracer and blue dye optimized the identification of SNs that drained GI cancers. Our preliminary data indicate that laparoscopic mapping of the SN is a sensitive intraoperative technique for identifying lymph node micrometastasis, and we believe that it will become an important component of a minimally invasive approach to early-stage GI cancers.

AB - Although the sentinel node (SN) concept has been validated in malignant melanoma and breast cancer, the application of this concept for other solid tumors, including gastrointestinal (GI) cancer, is still controversial. We have demonstrated the feasibility of radioguided SN mapping during laparotomy in patients with esophageal, gastric, and colorectal cancers. In 188 patients, the SNs identified by this technique had an overall diagnostic accuracy of 96% for regional lymph node metastasis. Aberrant drainage sites that have been called skip metastasis from the primary lesion were detectable using this method. More recently, we have undertaken SN mapping during laparoscopic surgery. A combination of radiotracer and blue dye optimized the identification of SNs that drained GI cancers. Our preliminary data indicate that laparoscopic mapping of the SN is a sensitive intraoperative technique for identifying lymph node micrometastasis, and we believe that it will become an important component of a minimally invasive approach to early-stage GI cancers.

UR - http://www.scopus.com/inward/record.url?scp=0034784386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034784386&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 86

EP - 89

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 9 SUPPL.

ER -