Laparoscopic subtotal gastrectomy for advanced gastric cancer

technical aspects and surgical, nutritional and oncological outcomes

Masaya Nakauchi, Koichi Suda, Kenichi Nakamura, Susumu Shibasaki, Kenji Kikuchi, Tetsuya Nakamura, Shinichi Kadoya, Yoshinori Ishida, Kazuki Inaba, Keizo Taniguchi, Ichiro Uyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Higher morbidity in total gastrectomy than in distal gastrectomy has been reported, but laparoscopic subtotal gastrectomy (LsTG) has been reported to be safe and feasible in early gastric cancer (GC). We determined the surgical, nutritional and oncological outcomes of LsTG for advanced gastric cancer (AGC). Methods: Of the 816 consecutive patients with GC who underwent radical gastrectomy at our institution between 2008 and 2012, 253 who underwent curative laparoscopic gastrectomy (LG) for AGC were enrolled. LsTG was indicated for patients with upper stomach third tumors, who hoped to avoid total gastrectomy, <4 cm to the esophagogastric junction and a 2-cm proximal margin with cut end negative in frozen section, whereas laparoscopic conventional distal gastrectomy (LcDG) and laparoscopic total gastrectomy (LTG) were performed otherwise. Surgical outcomes and postoperative nutritional status were primarily assessed. Results: Of 253 patients, the morbidity (Clavien–Dindo classification grade ≥ III) was 17.0% (43 patients). The 3-year overall survival and 3-year recurrence-free survival rates were 80.2 and 73.5%, respectively. LcDG, LsTG and LTG were performed in 121, 27 and 105 patients, individually. Morbidity was strongly associated with LTG (P = 0.001). Postoperative loss of body weight was significantly greater after LTG in comparison with LcDG or LsTG (P < 0.001). No difference in morbidity and postoperative loss of body weight were observed between LcDG and LsTG group. Conclusions: LG for AGC was feasible and safe surgically and oncologically. LsTG for AGC may be safer than LTG from surgical and postoperative nutritional point of view.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalSurgical Endoscopy and Other Interventional Techniques
DOIs
Publication statusAccepted/In press - 2017 Apr 7

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Gastrectomy
Stomach Neoplasms
Morbidity
Body Weight
Esophagogastric Junction

Keywords

  • Gastrectomy
  • Minimally invasive surgical procedures
  • Postoperative complications
  • Stomach neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Laparoscopic subtotal gastrectomy for advanced gastric cancer : technical aspects and surgical, nutritional and oncological outcomes. / Nakauchi, Masaya; Suda, Koichi; Nakamura, Kenichi; Shibasaki, Susumu; Kikuchi, Kenji; Nakamura, Tetsuya; Kadoya, Shinichi; Ishida, Yoshinori; Inaba, Kazuki; Taniguchi, Keizo; Uyama, Ichiro.

In: Surgical Endoscopy and Other Interventional Techniques, 07.04.2017, p. 1-10.

Research output: Contribution to journalArticle

Nakauchi, M, Suda, K, Nakamura, K, Shibasaki, S, Kikuchi, K, Nakamura, T, Kadoya, S, Ishida, Y, Inaba, K, Taniguchi, K & Uyama, I 2017, 'Laparoscopic subtotal gastrectomy for advanced gastric cancer: technical aspects and surgical, nutritional and oncological outcomes', Surgical Endoscopy and Other Interventional Techniques, pp. 1-10. https://doi.org/10.1007/s00464-017-5526-9
Nakauchi, Masaya ; Suda, Koichi ; Nakamura, Kenichi ; Shibasaki, Susumu ; Kikuchi, Kenji ; Nakamura, Tetsuya ; Kadoya, Shinichi ; Ishida, Yoshinori ; Inaba, Kazuki ; Taniguchi, Keizo ; Uyama, Ichiro. / Laparoscopic subtotal gastrectomy for advanced gastric cancer : technical aspects and surgical, nutritional and oncological outcomes. In: Surgical Endoscopy and Other Interventional Techniques. 2017 ; pp. 1-10.
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T2 - technical aspects and surgical, nutritional and oncological outcomes

AU - Nakauchi, Masaya

AU - Suda, Koichi

AU - Nakamura, Kenichi

AU - Shibasaki, Susumu

AU - Kikuchi, Kenji

AU - Nakamura, Tetsuya

AU - Kadoya, Shinichi

AU - Ishida, Yoshinori

AU - Inaba, Kazuki

AU - Taniguchi, Keizo

AU - Uyama, Ichiro

PY - 2017/4/7

Y1 - 2017/4/7

N2 - Background: Higher morbidity in total gastrectomy than in distal gastrectomy has been reported, but laparoscopic subtotal gastrectomy (LsTG) has been reported to be safe and feasible in early gastric cancer (GC). We determined the surgical, nutritional and oncological outcomes of LsTG for advanced gastric cancer (AGC). Methods: Of the 816 consecutive patients with GC who underwent radical gastrectomy at our institution between 2008 and 2012, 253 who underwent curative laparoscopic gastrectomy (LG) for AGC were enrolled. LsTG was indicated for patients with upper stomach third tumors, who hoped to avoid total gastrectomy, <4 cm to the esophagogastric junction and a 2-cm proximal margin with cut end negative in frozen section, whereas laparoscopic conventional distal gastrectomy (LcDG) and laparoscopic total gastrectomy (LTG) were performed otherwise. Surgical outcomes and postoperative nutritional status were primarily assessed. Results: Of 253 patients, the morbidity (Clavien–Dindo classification grade ≥ III) was 17.0% (43 patients). The 3-year overall survival and 3-year recurrence-free survival rates were 80.2 and 73.5%, respectively. LcDG, LsTG and LTG were performed in 121, 27 and 105 patients, individually. Morbidity was strongly associated with LTG (P = 0.001). Postoperative loss of body weight was significantly greater after LTG in comparison with LcDG or LsTG (P < 0.001). No difference in morbidity and postoperative loss of body weight were observed between LcDG and LsTG group. Conclusions: LG for AGC was feasible and safe surgically and oncologically. LsTG for AGC may be safer than LTG from surgical and postoperative nutritional point of view.

AB - Background: Higher morbidity in total gastrectomy than in distal gastrectomy has been reported, but laparoscopic subtotal gastrectomy (LsTG) has been reported to be safe and feasible in early gastric cancer (GC). We determined the surgical, nutritional and oncological outcomes of LsTG for advanced gastric cancer (AGC). Methods: Of the 816 consecutive patients with GC who underwent radical gastrectomy at our institution between 2008 and 2012, 253 who underwent curative laparoscopic gastrectomy (LG) for AGC were enrolled. LsTG was indicated for patients with upper stomach third tumors, who hoped to avoid total gastrectomy, <4 cm to the esophagogastric junction and a 2-cm proximal margin with cut end negative in frozen section, whereas laparoscopic conventional distal gastrectomy (LcDG) and laparoscopic total gastrectomy (LTG) were performed otherwise. Surgical outcomes and postoperative nutritional status were primarily assessed. Results: Of 253 patients, the morbidity (Clavien–Dindo classification grade ≥ III) was 17.0% (43 patients). The 3-year overall survival and 3-year recurrence-free survival rates were 80.2 and 73.5%, respectively. LcDG, LsTG and LTG were performed in 121, 27 and 105 patients, individually. Morbidity was strongly associated with LTG (P = 0.001). Postoperative loss of body weight was significantly greater after LTG in comparison with LcDG or LsTG (P < 0.001). No difference in morbidity and postoperative loss of body weight were observed between LcDG and LsTG group. Conclusions: LG for AGC was feasible and safe surgically and oncologically. LsTG for AGC may be safer than LTG from surgical and postoperative nutritional point of view.

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KW - Minimally invasive surgical procedures

KW - Postoperative complications

KW - Stomach neoplasms

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