Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case–Control Study

Takao Hinoi, Yasuo Kawaguchi, Minoru Hattori, Masazumi Okajima, Hideki Ohdan, Seiichiro Yamamoto, Hirotoshi Hasegawa, Hisanaga Horie, Kohei Murata, Shigeki Yamaguchi, Kenichi Sugihara, Masahiko Watanabe

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Abstract

Methods: We conducted a propensity scoring matched case–control study of colon and rectal cancer patients aged ≥80 years using data from 41 hospitals between 2003 and 2007. A total of 1,526 colon cancer patients and 282 rectal cancer patients underwent surgery and were included in the analysis. The primary end point was 3-year overall survival (OS). Secondary end points included disease-free survival (DFS), cancer-specific survival (CSS), and postoperative complications.

Results: LAP and OP were compared in 804 colon cancer patients (402 pairs) and 114 rectal cancer patients (57 pairs) after all covariates were balanced, and no significant differences were observed, except for tumor size in colon cancer. OS, DFS, and CSS did not differ between the groups for either colon cancer (P = 0.916, 0.968, and 0.799, respectively) or rectal cancer (P = 0.765, 0.519, and 0.950, respectively). In colon cancer cases, LAP was associated with fewer morbidities than was OP (24.9 vs. 36.3 %, P < 0.001); no such difference was observed for rectal cancer patients (47.4 vs. 40.4 %, P = 0.450).

Conclusions: LAP is an acceptable alternative to OP in elderly patients with colorectal cancer.

Background: The safety of laparoscopic surgery (LAP) in elderly patients with colorectal cancer has not been demonstrated. The aim of this study was to compare the outcomes of LAP and open surgery (OP) and estimate the feasibility of LAP in colorectal cancer patients aged ≥80 years.

Original languageEnglish
Pages (from-to)2040-2050
Number of pages11
JournalAnnals of Surgical Oncology
Volume22
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

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Colorectal Neoplasms
Laparoscopy
Colonic Neoplasms
Rectal Neoplasms
Survival
Disease-Free Survival
Neoplasms
Morbidity
Safety

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Hinoi, T., Kawaguchi, Y., Hattori, M., Okajima, M., Ohdan, H., Yamamoto, S., ... Watanabe, M. (2015). Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case–Control Study. Annals of Surgical Oncology, 22(6), 2040-2050. https://doi.org/10.1245/s10434-014-4172-x

Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients : A Multicenter Matched Case–Control Study. / Hinoi, Takao; Kawaguchi, Yasuo; Hattori, Minoru; Okajima, Masazumi; Ohdan, Hideki; Yamamoto, Seiichiro; Hasegawa, Hirotoshi; Horie, Hisanaga; Murata, Kohei; Yamaguchi, Shigeki; Sugihara, Kenichi; Watanabe, Masahiko.

In: Annals of Surgical Oncology, Vol. 22, No. 6, 01.06.2015, p. 2040-2050.

Research output: Contribution to journalArticle

Hinoi, T, Kawaguchi, Y, Hattori, M, Okajima, M, Ohdan, H, Yamamoto, S, Hasegawa, H, Horie, H, Murata, K, Yamaguchi, S, Sugihara, K & Watanabe, M 2015, 'Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case–Control Study', Annals of Surgical Oncology, vol. 22, no. 6, pp. 2040-2050. https://doi.org/10.1245/s10434-014-4172-x
Hinoi, Takao ; Kawaguchi, Yasuo ; Hattori, Minoru ; Okajima, Masazumi ; Ohdan, Hideki ; Yamamoto, Seiichiro ; Hasegawa, Hirotoshi ; Horie, Hisanaga ; Murata, Kohei ; Yamaguchi, Shigeki ; Sugihara, Kenichi ; Watanabe, Masahiko. / Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients : A Multicenter Matched Case–Control Study. In: Annals of Surgical Oncology. 2015 ; Vol. 22, No. 6. pp. 2040-2050.
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T2 - A Multicenter Matched Case–Control Study

AU - Hinoi, Takao

AU - Kawaguchi, Yasuo

AU - Hattori, Minoru

AU - Okajima, Masazumi

AU - Ohdan, Hideki

AU - Yamamoto, Seiichiro

AU - Hasegawa, Hirotoshi

AU - Horie, Hisanaga

AU - Murata, Kohei

AU - Yamaguchi, Shigeki

AU - Sugihara, Kenichi

AU - Watanabe, Masahiko

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N2 - Methods: We conducted a propensity scoring matched case–control study of colon and rectal cancer patients aged ≥80 years using data from 41 hospitals between 2003 and 2007. A total of 1,526 colon cancer patients and 282 rectal cancer patients underwent surgery and were included in the analysis. The primary end point was 3-year overall survival (OS). Secondary end points included disease-free survival (DFS), cancer-specific survival (CSS), and postoperative complications.Results: LAP and OP were compared in 804 colon cancer patients (402 pairs) and 114 rectal cancer patients (57 pairs) after all covariates were balanced, and no significant differences were observed, except for tumor size in colon cancer. OS, DFS, and CSS did not differ between the groups for either colon cancer (P = 0.916, 0.968, and 0.799, respectively) or rectal cancer (P = 0.765, 0.519, and 0.950, respectively). In colon cancer cases, LAP was associated with fewer morbidities than was OP (24.9 vs. 36.3 %, P < 0.001); no such difference was observed for rectal cancer patients (47.4 vs. 40.4 %, P = 0.450).Conclusions: LAP is an acceptable alternative to OP in elderly patients with colorectal cancer.Background: The safety of laparoscopic surgery (LAP) in elderly patients with colorectal cancer has not been demonstrated. The aim of this study was to compare the outcomes of LAP and open surgery (OP) and estimate the feasibility of LAP in colorectal cancer patients aged ≥80 years.

AB - Methods: We conducted a propensity scoring matched case–control study of colon and rectal cancer patients aged ≥80 years using data from 41 hospitals between 2003 and 2007. A total of 1,526 colon cancer patients and 282 rectal cancer patients underwent surgery and were included in the analysis. The primary end point was 3-year overall survival (OS). Secondary end points included disease-free survival (DFS), cancer-specific survival (CSS), and postoperative complications.Results: LAP and OP were compared in 804 colon cancer patients (402 pairs) and 114 rectal cancer patients (57 pairs) after all covariates were balanced, and no significant differences were observed, except for tumor size in colon cancer. OS, DFS, and CSS did not differ between the groups for either colon cancer (P = 0.916, 0.968, and 0.799, respectively) or rectal cancer (P = 0.765, 0.519, and 0.950, respectively). In colon cancer cases, LAP was associated with fewer morbidities than was OP (24.9 vs. 36.3 %, P < 0.001); no such difference was observed for rectal cancer patients (47.4 vs. 40.4 %, P = 0.450).Conclusions: LAP is an acceptable alternative to OP in elderly patients with colorectal cancer.Background: The safety of laparoscopic surgery (LAP) in elderly patients with colorectal cancer has not been demonstrated. The aim of this study was to compare the outcomes of LAP and open surgery (OP) and estimate the feasibility of LAP in colorectal cancer patients aged ≥80 years.

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