Laser-driven short-duration heating angioplasty

Chronic artery lumen patency and histology in porcine iliac artery

Natsumi Shimazaki, Mie Kunio, Sho Naruse, Tsunenori Arai, Masami Sakurada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We proposed a short-duration heating balloon angioplasty. We designed a prototype short-duration heating balloon catheter that can heat artery media to 60-70°C within 15-25 s with a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. The purpose of this study was to investigate chronic artery lumen patency as well as histological alteration of artery wall after the short-duration heating balloon dilatation with porcine healthy iliac artery. The short-term heating balloon dilated sites were angiographically patent in acute (1 hour) and in chronic phases (1 and 4 weeks). One week after the dilatation, smooth muscle cells (SMCs) density in the artery media measured from H&E-stained specimens was approx. 20% lower than that in the reference artery. One and four weeks after the dilatations, normal structure of artery adventitia was maintained without any incidence of thermal injury. Normal lamellar structure of the artery media was also maintained. We found that the localized heating restricted to artery media by the short-duration heating could maintain adventitial function and artery normal structure in chronic phase.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
DOIs
Publication statusPublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: 2012 Jan 212012 Jan 24

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period12/1/2112/1/24

Fingerprint

Histology
lumens
histology
Iliac Artery
arteries
Angioplasty
Heating
Balloons
Lasers
Swine
Arteries
heating
balloons
lasers
Dilatation
Adventitia
Hot Temperature
Lamellar structures
Catheters
Heat generation

Keywords

  • Artery histology
  • Balloon angioplasty
  • Thermal angioplasty

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Shimazaki, N., Kunio, M., Naruse, S., Arai, T., & Sakurada, M. (2012). Laser-driven short-duration heating angioplasty: Chronic artery lumen patency and histology in porcine iliac artery. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8207). [82074F] https://doi.org/10.1117/12.909870

Laser-driven short-duration heating angioplasty : Chronic artery lumen patency and histology in porcine iliac artery. / Shimazaki, Natsumi; Kunio, Mie; Naruse, Sho; Arai, Tsunenori; Sakurada, Masami.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012. 82074F.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shimazaki, N, Kunio, M, Naruse, S, Arai, T & Sakurada, M 2012, Laser-driven short-duration heating angioplasty: Chronic artery lumen patency and histology in porcine iliac artery. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8207, 82074F, Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, United States, 12/1/21. https://doi.org/10.1117/12.909870
Shimazaki N, Kunio M, Naruse S, Arai T, Sakurada M. Laser-driven short-duration heating angioplasty: Chronic artery lumen patency and histology in porcine iliac artery. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207. 2012. 82074F https://doi.org/10.1117/12.909870
Shimazaki, Natsumi ; Kunio, Mie ; Naruse, Sho ; Arai, Tsunenori ; Sakurada, Masami. / Laser-driven short-duration heating angioplasty : Chronic artery lumen patency and histology in porcine iliac artery. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012.
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