Laser-driven short-duration heating angioplasty: Dilatation performance in cadaver atherosclerotic femoral arteries

Natsumi Shimazaki, Sho Naruse, Tsunenori Arai, Nobuaki Imanishi, Sadakazu Aiso

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study was to investigate the artery dilatation performance of the short-duration heating balloon catheter in cadaver stenotic arteries. We designed a prototype short-duration heating balloon catheter that can heat artery media to around 60 °C in 15-25 s by a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. We performed ex vivo short-duration heating dilatation in the cadaver atherosclerotic femoral arteries (initial percent diameter stenosis was 36-98%), with the maximum balloon temperature of 65±5 °C, laser irradiation duration of 25 s, and balloon dilatation pressure of 3.5 atm. The artery lumen configurations before and after the dilatations were assessed with a commercial IVUS system. After the short-duration heating dilatations, the percent diameter stenosis was reduced below 30% without any artery tears or dissections. We estimated that the artery media temperature was raised to around 60 °C in which plaque thickness was below 0.8 mm by a thermal conduction calculation. The estimated maximum temperature in artery adventitia and surrounding tissue was up to 45 °C. We found that the short-duration heating balloon could sufficiently dilate the cadaver stenotic arteries, without thermal injury in artery adventitia and surroundings.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics IX
DOIs
Publication statusPublished - 2013 May 30
EventPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
Duration: 2013 Feb 22013 Feb 7

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8565
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics IX
CountryUnited States
CitySan Francisco, CA
Period13/2/213/2/7

    Fingerprint

Keywords

  • Balloon angioplasty
  • Extracted human cadaver artery
  • Thermal angioplasty

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Shimazaki, N., Naruse, S., Arai, T., Imanishi, N., & Aiso, S. (2013). Laser-driven short-duration heating angioplasty: Dilatation performance in cadaver atherosclerotic femoral arteries. In Photonic Therapeutics and Diagnostics IX [85654E] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8565). https://doi.org/10.1117/12.2005432