Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

Kazumasa Ariyasu, Atsuhiro Ishii, Taiga Umemoto, Mitsuhiro Terakawa

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.

    Original languageEnglish
    Article number085003
    JournalJournal of Biomedical Optics
    Volume21
    Issue number8
    DOIs
    Publication statusPublished - 2016 Aug 1

    Keywords

    • Biodegradable polymer
    • Drug delivery
    • Drug release
    • Femtosecond laser
    • Microcapsule

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering

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