Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

Kazumasa Ariyasu, Atsuhiro Ishii, Taiga Umemoto, Mitsuhiro Terakawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.

Original languageEnglish
Article number085003
JournalJournal of Biomedical Optics
Volume21
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

glycolic acid
Capsules
acids
Molecules
Acids
Lasers
lasers
molecules
Ultrashort pulses
coaxial nozzles
Biodegradable polymers
dextrans
encapsulating
Dextran
controllability
pulses
Controllability
infrared lasers
bursts
Nozzles

Keywords

  • Biodegradable polymer
  • Drug delivery
  • Drug release
  • Femtosecond laser
  • Microcapsule

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules. / Ariyasu, Kazumasa; Ishii, Atsuhiro; Umemoto, Taiga; Terakawa, Mitsuhiro.

In: Journal of Biomedical Optics, Vol. 21, No. 8, 085003, 01.08.2016.

Research output: Contribution to journalArticle

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