Late complications after surgery in patients with neuroblastoma

Tatsuo Kuroda, Morihiro Saeki, Toshiro Honna, Masaaki Kumagai, Hidekazu Masaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: The purpose of this study was 2-fold: to study the complications of neuroblastoma treatment and to establish surgical guidelines. Materials and Methods: The medical records of 92 patients with neuroblastoma (stage 1 or 2, n = 33; stage 3, n = 21; stage 4, n = 31; stage 4S, n = 7) who had undergone surgery in our department between 1985 and 2001 were reviewed, with an emphasis on treatments and late complications. Results: The disease-free survival rate was 98.3% (58/59) in infantile patients, whereas it was 36.4% (12/33) in advanced patients older than 1 year. The rate was improved up to greater than 50% after the introduction of intensive local therapy with intraoperative radiation (IOR). The treatment-associated morbidity rate was 15.0% in nonadvanced infantile patients, was 42.1% in advanced infantile patients, and was 33.3% in advanced older patients. In the advanced cases, renovascular problems were most frequently seen especially after IOR. Furthermore, pulmonary problems, cardiac problems, and second cancer were highlighted as fatal problems; thyroid dysfunction, vertebral deformity, and growth retardation were also noted. Conclusions: Higher incidences of late morbidity and treatment-associated mortality appeared to be more strongly related to disease stage rather than to patient age. Appropriate surgery and IOR with lower doses should be recommended as a surgical strategy for high-risk patients.

Original languageEnglish
Pages (from-to)2037-2040
Number of pages4
JournalJournal of Pediatric Surgery
Volume41
Issue number12
DOIs
Publication statusPublished - 2006 Dec
Externally publishedYes

Fingerprint

Neuroblastoma
Radiation
Morbidity
Therapeutics
Heart Neoplasms
Second Primary Neoplasms
Disease-Free Survival
Medical Records
Thyroid Gland
Survival Rate
Guidelines
Lung
Mortality
Incidence
Growth

Keywords

  • Complication
  • Intraoperative radiation
  • Neuroblastoma

ASJC Scopus subject areas

  • Surgery

Cite this

Late complications after surgery in patients with neuroblastoma. / Kuroda, Tatsuo; Saeki, Morihiro; Honna, Toshiro; Kumagai, Masaaki; Masaki, Hidekazu.

In: Journal of Pediatric Surgery, Vol. 41, No. 12, 12.2006, p. 2037-2040.

Research output: Contribution to journalArticle

Kuroda, Tatsuo ; Saeki, Morihiro ; Honna, Toshiro ; Kumagai, Masaaki ; Masaki, Hidekazu. / Late complications after surgery in patients with neuroblastoma. In: Journal of Pediatric Surgery. 2006 ; Vol. 41, No. 12. pp. 2037-2040.
@article{86797286d00f4391819fc25feaf06781,
title = "Late complications after surgery in patients with neuroblastoma",
abstract = "Purpose: The purpose of this study was 2-fold: to study the complications of neuroblastoma treatment and to establish surgical guidelines. Materials and Methods: The medical records of 92 patients with neuroblastoma (stage 1 or 2, n = 33; stage 3, n = 21; stage 4, n = 31; stage 4S, n = 7) who had undergone surgery in our department between 1985 and 2001 were reviewed, with an emphasis on treatments and late complications. Results: The disease-free survival rate was 98.3{\%} (58/59) in infantile patients, whereas it was 36.4{\%} (12/33) in advanced patients older than 1 year. The rate was improved up to greater than 50{\%} after the introduction of intensive local therapy with intraoperative radiation (IOR). The treatment-associated morbidity rate was 15.0{\%} in nonadvanced infantile patients, was 42.1{\%} in advanced infantile patients, and was 33.3{\%} in advanced older patients. In the advanced cases, renovascular problems were most frequently seen especially after IOR. Furthermore, pulmonary problems, cardiac problems, and second cancer were highlighted as fatal problems; thyroid dysfunction, vertebral deformity, and growth retardation were also noted. Conclusions: Higher incidences of late morbidity and treatment-associated mortality appeared to be more strongly related to disease stage rather than to patient age. Appropriate surgery and IOR with lower doses should be recommended as a surgical strategy for high-risk patients.",
keywords = "Complication, Intraoperative radiation, Neuroblastoma",
author = "Tatsuo Kuroda and Morihiro Saeki and Toshiro Honna and Masaaki Kumagai and Hidekazu Masaki",
year = "2006",
month = "12",
doi = "10.1016/j.jpedsurg.2006.08.003",
language = "English",
volume = "41",
pages = "2037--2040",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "12",

}

TY - JOUR

T1 - Late complications after surgery in patients with neuroblastoma

AU - Kuroda, Tatsuo

AU - Saeki, Morihiro

AU - Honna, Toshiro

AU - Kumagai, Masaaki

AU - Masaki, Hidekazu

PY - 2006/12

Y1 - 2006/12

N2 - Purpose: The purpose of this study was 2-fold: to study the complications of neuroblastoma treatment and to establish surgical guidelines. Materials and Methods: The medical records of 92 patients with neuroblastoma (stage 1 or 2, n = 33; stage 3, n = 21; stage 4, n = 31; stage 4S, n = 7) who had undergone surgery in our department between 1985 and 2001 were reviewed, with an emphasis on treatments and late complications. Results: The disease-free survival rate was 98.3% (58/59) in infantile patients, whereas it was 36.4% (12/33) in advanced patients older than 1 year. The rate was improved up to greater than 50% after the introduction of intensive local therapy with intraoperative radiation (IOR). The treatment-associated morbidity rate was 15.0% in nonadvanced infantile patients, was 42.1% in advanced infantile patients, and was 33.3% in advanced older patients. In the advanced cases, renovascular problems were most frequently seen especially after IOR. Furthermore, pulmonary problems, cardiac problems, and second cancer were highlighted as fatal problems; thyroid dysfunction, vertebral deformity, and growth retardation were also noted. Conclusions: Higher incidences of late morbidity and treatment-associated mortality appeared to be more strongly related to disease stage rather than to patient age. Appropriate surgery and IOR with lower doses should be recommended as a surgical strategy for high-risk patients.

AB - Purpose: The purpose of this study was 2-fold: to study the complications of neuroblastoma treatment and to establish surgical guidelines. Materials and Methods: The medical records of 92 patients with neuroblastoma (stage 1 or 2, n = 33; stage 3, n = 21; stage 4, n = 31; stage 4S, n = 7) who had undergone surgery in our department between 1985 and 2001 were reviewed, with an emphasis on treatments and late complications. Results: The disease-free survival rate was 98.3% (58/59) in infantile patients, whereas it was 36.4% (12/33) in advanced patients older than 1 year. The rate was improved up to greater than 50% after the introduction of intensive local therapy with intraoperative radiation (IOR). The treatment-associated morbidity rate was 15.0% in nonadvanced infantile patients, was 42.1% in advanced infantile patients, and was 33.3% in advanced older patients. In the advanced cases, renovascular problems were most frequently seen especially after IOR. Furthermore, pulmonary problems, cardiac problems, and second cancer were highlighted as fatal problems; thyroid dysfunction, vertebral deformity, and growth retardation were also noted. Conclusions: Higher incidences of late morbidity and treatment-associated mortality appeared to be more strongly related to disease stage rather than to patient age. Appropriate surgery and IOR with lower doses should be recommended as a surgical strategy for high-risk patients.

KW - Complication

KW - Intraoperative radiation

KW - Neuroblastoma

UR - http://www.scopus.com/inward/record.url?scp=33845188649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845188649&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2006.08.003

DO - 10.1016/j.jpedsurg.2006.08.003

M3 - Article

VL - 41

SP - 2037

EP - 2040

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 12

ER -