Late-onset invasive group B streptococcal infection with serotype VIII in a neonate having congenital biliary atresia

Tomoaki Takei, Naoko Chiba, Hisayo Fujita, Miyuki Morozumi, Yusuke Kuwata, Kozue Kishii, Kimiko Ubukata, Satoshi Iwata, Takashi Takahashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A female newborn was admitted to our department 15 days after birth for insufficient sucking and jaundice. The patient's blood and urine cultures were both positive for group B streptococcal (GBS) infection. A maternal vaginal sample at 35 weeks' gestation was negative for GBS in culture-based microbiologic screening. The patient recovered shortly after receiving systemic antibiotic therapy. On the basis of clinical evidence of white stool and progressive jaundice, we suspected that the newborn had complications related to congenital biliary atresia (CBA); surgery was performed. Isolates from the mother's vaginal sample obtained when the patient was 25 days old, along with neonatal blood, revealed identical patterns (serotype VIII and sequence type 1) of GBS capsular and multilocus sequence typing, suggestive of maternal transmission. Molecular epidemiologic examination may be useful to clarify the transmission route and etiology; culture-based microbiologic screening appears to have limitations for detecting the route of transmission.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalPediatrics and Neonatology
Volume54
Issue number1
DOIs
Publication statusPublished - 2013 Feb
Externally publishedYes

Fingerprint

Biliary Atresia
Streptococcal Infections
Mothers
Newborn Infant
Jaundice
Multilocus Sequence Typing
Urine
Parturition
Anti-Bacterial Agents
Pregnancy
Serogroup
Therapeutics

Keywords

  • group B streptococcus
  • invasive infection
  • late onset
  • serotype VIII

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Late-onset invasive group B streptococcal infection with serotype VIII in a neonate having congenital biliary atresia. / Takei, Tomoaki; Chiba, Naoko; Fujita, Hisayo; Morozumi, Miyuki; Kuwata, Yusuke; Kishii, Kozue; Ubukata, Kimiko; Iwata, Satoshi; Takahashi, Takashi.

In: Pediatrics and Neonatology, Vol. 54, No. 1, 02.2013, p. 63-66.

Research output: Contribution to journalArticle

Takei, Tomoaki ; Chiba, Naoko ; Fujita, Hisayo ; Morozumi, Miyuki ; Kuwata, Yusuke ; Kishii, Kozue ; Ubukata, Kimiko ; Iwata, Satoshi ; Takahashi, Takashi. / Late-onset invasive group B streptococcal infection with serotype VIII in a neonate having congenital biliary atresia. In: Pediatrics and Neonatology. 2013 ; Vol. 54, No. 1. pp. 63-66.
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