Late-onset type 1 diabetes mellitus in an elderly Japanese woman with single positive insulinoma-associated tyrosine phosphatase-like protein-2 (IA-2) antibody

Masuomi Tomita, Yusuke Kabeya, Yasuaki Yashiro, Toshikatsu Sigihara, Shu Meguro, Yoshihito Atsumi

Research output: Contribution to journalArticle

Abstract

A 79-year-old Japanese old woman hospitalized to assess elevated plasma glucose of 499 mg/dl, HbA1c 6.0%, and positive urine ketone bodies on January 13,2006, had a urinary C peptide concentration of 11.3 μg/day, indicating decreasing insulin secretion. Although antiglutamic acid dehydrogenase (GAD) antibody was negative, she was suspected to have "fulminant type 1 diabetes" due to the rapid onset. She was also diagnosed with autoimmune-related type 1 diabetes mellitus due to high IA-2 antibody (27U/ml). She was treated with insulin during hospitalization. We consider this worth reporting, because very few cases of senile onset type 1 diabetes mellitus are positive for IA-2 antibody.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalJournal of the Japan Diabetes Society
Volume51
Issue number3
Publication statusPublished - 2008
Externally publishedYes

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Protein Phosphatase 2
Insulinoma
Type 1 Diabetes Mellitus
Tyrosine
Insulin
Ketone Bodies
C-Peptide
Oxidoreductases
Hospitalization
Urine
Glucose
Acids
Antibodies
ICA512 autoantibody

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Late-onset type 1 diabetes mellitus in an elderly Japanese woman with single positive insulinoma-associated tyrosine phosphatase-like protein-2 (IA-2) antibody. / Tomita, Masuomi; Kabeya, Yusuke; Yashiro, Yasuaki; Sigihara, Toshikatsu; Meguro, Shu; Atsumi, Yoshihito.

In: Journal of the Japan Diabetes Society, Vol. 51, No. 3, 2008, p. 245-249.

Research output: Contribution to journalArticle

Tomita, Masuomi ; Kabeya, Yusuke ; Yashiro, Yasuaki ; Sigihara, Toshikatsu ; Meguro, Shu ; Atsumi, Yoshihito. / Late-onset type 1 diabetes mellitus in an elderly Japanese woman with single positive insulinoma-associated tyrosine phosphatase-like protein-2 (IA-2) antibody. In: Journal of the Japan Diabetes Society. 2008 ; Vol. 51, No. 3. pp. 245-249.
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