Late-onset type 1 diabetes mellitus in an elderly Japanese woman with single positive insulinoma-associated tyrosine phosphatase-like protein-2 (IA-2) antibody

Masuomi Tomita, Yusuke Kabeya, Yasuaki Yashiro, Toshikatsu Sigihara, Shu Meguro, Yoshihito Atsumi

Research output: Contribution to journalArticle

Abstract

A 79-year-old Japanese old woman hospitalized to assess elevated plasma glucose of 499 mg/dl, HbA1c 6.0%, and positive urine ketone bodies on January 13,2006, had a urinary C peptide concentration of 11.3 μg/day, indicating decreasing insulin secretion. Although antiglutamic acid dehydrogenase (GAD) antibody was negative, she was suspected to have "fulminant type 1 diabetes" due to the rapid onset. She was also diagnosed with autoimmune-related type 1 diabetes mellitus due to high IA-2 antibody (27U/ml). She was treated with insulin during hospitalization. We consider this worth reporting, because very few cases of senile onset type 1 diabetes mellitus are positive for IA-2 antibody.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalJournal of the Japan Diabetes Society
Volume51
Issue number3
Publication statusPublished - 2008 Jun 2
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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