Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

Research output: Contribution to journalArticle

Abstract

Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

Original languageEnglish
Article numbere13121
JournalTransplant Infectious Disease
DOIs
Publication statusPublished - 2019 Jan 1

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Human Herpesvirus 3
Acute Liver Failure
Hematopoietic Stem Cell Transplantation
Virus Diseases
Herpes Zoster
Transplants
Infection

Keywords

  • acute liver failure
  • allogeneic hematopoietic stem cell transplantation
  • varicella-zoster virus

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

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title = "Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation",
abstract = "Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.",
keywords = "acute liver failure, allogeneic hematopoietic stem cell transplantation, varicella-zoster virus",
author = "Taku Kikuchi and Mari Arai and Yuya Koda and Jun Kato and Takayuki Shimizu and Harutaka Katano and Yoko Nishimura and Michiie Sakamoto and Hirotoshi Ebinuma and Nobuhiro Nakamoto and Takanori Kanai and Shinichiro Okamoto and Takehiko Mori",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/tid.13121",
language = "English",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

AU - Kikuchi, Taku

AU - Arai, Mari

AU - Koda, Yuya

AU - Kato, Jun

AU - Shimizu, Takayuki

AU - Katano, Harutaka

AU - Nishimura, Yoko

AU - Sakamoto, Michiie

AU - Ebinuma, Hirotoshi

AU - Nakamoto, Nobuhiro

AU - Kanai, Takanori

AU - Okamoto, Shinichiro

AU - Mori, Takehiko

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

AB - Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

KW - acute liver failure

KW - allogeneic hematopoietic stem cell transplantation

KW - varicella-zoster virus

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