Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

Taku Kikuchi, Mari Arai, Yuya Koda, Jun Kato, Takayuki Shimizu, Harutaka Katano, Yoko Fujii-Nishimura, Michiie Sakamoto, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Takanori Kanai, Shinichiro Okamoto, Takehiko Mori

Research output: Contribution to journalArticlepeer-review

Abstract

Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

Original languageEnglish
Article numbere13121
JournalTransplant Infectious Disease
Volume21
Issue number4
DOIs
Publication statusPublished - 2019

Keywords

  • acute liver failure
  • allogeneic hematopoietic stem cell transplantation
  • varicella-zoster virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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