Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

Taku Kikuchi; Mari Arai; Yuya Koda; Jun Kato; Takayuki Shimizu; Harutaka Katano; Yoko Fujii-Nishimura; Michiie Sakamoto; Hirotoshi Ebinuma; Nobuhiro Nakamoto; Takanori Kanai; Shinichiro Okamoto; Takehiko Mori

doi:10.1111/tid.13121

Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

Taku Kikuchi, Mari Arai, Yuya Koda, Jun Kato, Takayuki Shimizu, Harutaka Katano, Yoko Fujii-Nishimura, Michiie Sakamoto, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Takanori Kanai, Shinichiro Okamoto, Takehiko Mori

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

Original language	English
Article number	e13121
Journal	Transplant Infectious Disease
Volume	21
Issue number	4
DOIs	https://doi.org/10.1111/tid.13121
Publication status	Published - 2019

Keywords

acute liver failure
allogeneic hematopoietic stem cell transplantation
varicella-zoster virus

ASJC Scopus subject areas

Transplantation
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.13121

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Kikuchi, T., Arai, M., Koda, Y., Kato, J., Shimizu, T., Katano, H., Fujii-Nishimura, Y., Sakamoto, M., Ebinuma, H., Nakamoto, N., Kanai, T., Okamoto, S., & Mori, T. (2019). Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation. Transplant Infectious Disease, 21(4), [e13121]. https://doi.org/10.1111/tid.13121

Kikuchi, T, Arai, M, Koda, Y , Kato, J , Shimizu, T, Katano, H, Fujii-Nishimura, Y, Sakamoto, M, Ebinuma, H, Nakamoto, N , Kanai, T, Okamoto, S & Mori, T 2019, 'Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation', Transplant Infectious Disease, vol. 21, no. 4, e13121. https://doi.org/10.1111/tid.13121

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abstract = "Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.",

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doi = "10.1111/tid.13121",

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AU - Kikuchi, Taku

AU - Arai, Mari

AU - Koda, Yuya

AU - Kato, Jun

AU - Shimizu, Takayuki

AU - Katano, Harutaka

AU - Fujii-Nishimura, Yoko

AU - Sakamoto, Michiie

AU - Ebinuma, Hirotoshi

AU - Nakamoto, Nobuhiro

AU - Kanai, Takanori

AU - Okamoto, Shinichiro

AU - Mori, Takehiko

PY - 2019

Y1 - 2019

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AB - Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

KW - acute liver failure

KW - allogeneic hematopoietic stem cell transplantation

KW - varicella-zoster virus

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Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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