Late-onset visceral varicella-zoster virus infection presented as acute liver failure after allogeneic hematopoietic stem cell transplantation

Taku Kikuchi, Mari Arai, Yuya Koda, Jun Kato, Takayuki Shimizu, Harutaka Katano, Yoko Nishimura, Michiie Sakamoto, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Takanori Kanai, Shinichiro Okamoto, Takehiko Mori

Research output: Contribution to journalArticle


Although much less common than localized zoster, initial presentation of varicella-zoster virus (VZV) as visceral infection can occur especially after allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of post-transplant visceral VZV infection presenting as fatal acute liver failure. It developed 4 years after allogeneic HSCT when a long-term prophylactic anti-VZV agent administration was discontinued. VZV should be listed as a causative pathogen of acute liver failure even years after allogeneic HSCT. Indication for, and duration of anti-VZV prophylaxis should be further investigated.

Original languageEnglish
Article numbere13121
JournalTransplant Infectious Disease
Publication statusPublished - 2019 Jan 1



  • acute liver failure
  • allogeneic hematopoietic stem cell transplantation
  • varicella-zoster virus

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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