Lead accumulation as possible risk factor for primary open-angle glaucoma

Kenya Yuki, Murat Dogru, Yutaka Imamura, Itaru Kimura, Yuichiro Ohtake, Kazuo Tsubota

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We evaluated the association between hair lead concentrations and primary open-angle glaucoma. Ninety-eight Japanese patients (40 males, 58 females; average age 57.6±10.8 years) with primary open-angle glaucoma and control subjects (131 males, 114 females; average age 56.0±12.8 years) were recruited in this study. Hair lead levels were measured by inductively coupled plasma mass spectrometry. Hair lead concentrations between primary open-angle glaucoma and control groups were compared using Mann-Whitney U test. As a subgroup analysis, we compared hair lead concentrations between low-tension glaucoma, high-tension glaucoma, and control groups using one-factor analysis of variance. Lead accumulation levels were significantly higher in the female subjects with primary open-angle glaucoma compared to the control group (P=0.03). Lead accumulation levels were significantly higher in female patients with low intraocular pressure compared to control group 2 (P=0.02). A higher hair lead level, which reflects the total body burden of lead, was observed to be associated with primary open-angle glaucoma in females especially with low-tension glaucoma. Accumulation of lead may be an unrecognized risk factor of non-pressure-dependent glaucomatous optic neuropathy.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiological Trace Element Research
Volume132
Issue number1-3
DOIs
Publication statusPublished - 2009 Jan

Fingerprint

Hair
Low Tension Glaucoma
Control Groups
Body Burden
Inductively coupled plasma mass spectrometry
Optic Nerve Diseases
Factor analysis
Nonparametric Statistics
Analysis of variance (ANOVA)
Primary Open Angle Glaucoma
Lead
Intraocular Pressure
Glaucoma
Statistical Factor Analysis
Optics
Mass Spectrometry
Analysis of Variance

Keywords

  • Hair
  • Inductively coupled plasma mass spectrometry
  • Lead
  • Neurotoxicity
  • Primary open-angle glaucoma

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Lead accumulation as possible risk factor for primary open-angle glaucoma. / Yuki, Kenya; Dogru, Murat; Imamura, Yutaka; Kimura, Itaru; Ohtake, Yuichiro; Tsubota, Kazuo.

In: Biological Trace Element Research, Vol. 132, No. 1-3, 01.2009, p. 1-8.

Research output: Contribution to journalArticle

Yuki, Kenya ; Dogru, Murat ; Imamura, Yutaka ; Kimura, Itaru ; Ohtake, Yuichiro ; Tsubota, Kazuo. / Lead accumulation as possible risk factor for primary open-angle glaucoma. In: Biological Trace Element Research. 2009 ; Vol. 132, No. 1-3. pp. 1-8.
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