Lectin-Induced Aggregation of Glycophorin-Reconstituted Liposomes

Junzo Sunamoto, Mitsuaki Goto, Motoomi Arakawa, Toshinori Sato, Hiroki Kondo, Daisuke Tsuru

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to make an artificial cell (liposome) tougher and morecell specific for biotechnolo-gical utilization, a glycophorin-reconstituted liposome bearing an artificial boundary lipid in its bilayer membrane has been newly developed. The synthesized boundary lipid, 1, 2-dimyristoylamido-l, 2-deoxyphosphatidylcholine (DDPC), carries an amide bond instead of the carboxylic ester bond in common phosphatidylcholines. This modified lipid holds a membrane protein more effectively in the liposomal membrane than does sphingomyelin in nature. Moreover, enzymatic treatment of saccharide moiety of glycpphorin on the liposomal surface brought about a change of the specificity of artificial cell to lectins and phagocytes. Therefore, the saccharide moiety of glycophorin was considered to play a role as an effective sensory device for molecular recognition on the surface of the artificial cell of liposome.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalNippon Kagaku Kaishi
Volume1987
Issue number3
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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