Left circumflex coronary artery is protected against no-reflow phenomenon following percutaneous coronary intervention for coronary artery disease

Toshiyuki Nagai, Takuro Hirano, Mayumi Tsunoda, Haruhiko Hosaka, Yoshikazu Kishino, Takaharu Katayama, Keisuke Matsumura, Takashi Miyagawa, Shun Kosaka, Toshihisa Anzai, Keiichi Fukuda, Masahiro Suzuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Despite the positive impact of percutaneous coronary intervention (PCI) on reducing mortality, a small percentage of patients experience poor myocardial reperfusion following PCI. However, factors associated with no-reflow remain unclear. We investigated clinical factors associated with no-reflow following PCI for coronary artery disease (CAD). We retrospectively analyzed 1622 consecutive CAD patients who underwent PCI over a 5-year period at our institution. Patients were divided into two groups according to the presence (n = 31) or absence (n = 1591) of no-reflow, defined as Thrombolysis in Myocardial Infarction flow grade <3 after PCI. No significant differences in patient characteristics or PCI strategy were seen between the no-reflow and normal flow groups. The incidence of no-reflow was significantly lower in the left circumflex artery (LCx) than in the left anterior descending artery (LAD) (P = 0.0015), with no differences in characteristics or PCI strategy between these two target vessels. Multivariate analysis revealed that involvement of the LCx was an independent protective factor against no-reflow (odds ratio 0.14, 95 % confidence interval 0.02-0.98, P = 0.044). In conclusion, LCx as the target vessel was protective against no-reflow compared with LAD following PCI for CAD. Our results suggest that embolic protection devices may be unnecessary in CAD patients with involvement of LCx.

Original languageEnglish
Pages (from-to)559-565
Number of pages7
JournalHeart and Vessels
Volume28
Issue number5
DOIs
Publication statusPublished - 2013 Sep

Fingerprint

No-Reflow Phenomenon
Percutaneous Coronary Intervention
Coronary Artery Disease
Coronary Vessels
Arteries
Embolic Protection Devices
Myocardial Reperfusion
Multivariate Analysis
Odds Ratio
Myocardial Infarction
Confidence Intervals

Keywords

  • Coronary artery disease
  • No-reflow phenomenon
  • Percutaneous coronary intervention
  • Target vessel

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Left circumflex coronary artery is protected against no-reflow phenomenon following percutaneous coronary intervention for coronary artery disease. / Nagai, Toshiyuki; Hirano, Takuro; Tsunoda, Mayumi; Hosaka, Haruhiko; Kishino, Yoshikazu; Katayama, Takaharu; Matsumura, Keisuke; Miyagawa, Takashi; Kosaka, Shun; Anzai, Toshihisa; Fukuda, Keiichi; Suzuki, Masahiro.

In: Heart and Vessels, Vol. 28, No. 5, 09.2013, p. 559-565.

Research output: Contribution to journalArticle

Nagai, T, Hirano, T, Tsunoda, M, Hosaka, H, Kishino, Y, Katayama, T, Matsumura, K, Miyagawa, T, Kosaka, S, Anzai, T, Fukuda, K & Suzuki, M 2013, 'Left circumflex coronary artery is protected against no-reflow phenomenon following percutaneous coronary intervention for coronary artery disease', Heart and Vessels, vol. 28, no. 5, pp. 559-565. https://doi.org/10.1007/s00380-012-0281-2
Nagai, Toshiyuki ; Hirano, Takuro ; Tsunoda, Mayumi ; Hosaka, Haruhiko ; Kishino, Yoshikazu ; Katayama, Takaharu ; Matsumura, Keisuke ; Miyagawa, Takashi ; Kosaka, Shun ; Anzai, Toshihisa ; Fukuda, Keiichi ; Suzuki, Masahiro. / Left circumflex coronary artery is protected against no-reflow phenomenon following percutaneous coronary intervention for coronary artery disease. In: Heart and Vessels. 2013 ; Vol. 28, No. 5. pp. 559-565.
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