Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Keiichi Hishikawa, Takeshi Marumo, Shigeki Miura, Asato Nakanishi, Yumi Matsuzaki, Katsunori Shibata, Hiroko Kohike, Takuya Komori, Matsuhiko Hayashi, Toshio Nakaki, Hiromitsu Nakauchi, Hideyuki Okano, Toshiro Fujita

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.

Original languageEnglish
Pages (from-to)288-291
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume328
Issue number1
DOIs
Publication statusPublished - 2005 Mar 4

Keywords

  • Cadherin 16
  • Regenerative medicine
  • Stem cell

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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