Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Keiichi Hishikawa; Takeshi Marumo; Shigeki Miura; Asato Nakanishi; Yumi Matsuzaki; Katsunori Shibata; Hiroko Kohike; Takuya Komori; Matsuhiko Hayashi; Toshio Nakaki; Hiromitsu Nakauchi; Hideyuki Okano; Toshiro Fujita

doi:10.1016/j.bbrc.2004.12.167

Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Keiichi Hishikawa, Takeshi Marumo, Shigeki Miura, Asato Nakanishi, Yumi Matsuzaki, Katsunori Shibata, Hiroko Kohike, Takuya Komori, Matsuhiko Hayashi, Toshio Nakaki, Hiromitsu Nakauchi, Hideyuki Okano, Toshiro Fujita

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.

Original language	English
Pages (from-to)	288-291
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	328
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2004.12.167
Publication status	Published - 2005 Mar 4

Keywords

Cadherin 16
Regenerative medicine
Stem cell

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Hishikawa, K., Marumo, T., Miura, S., Nakanishi, A., Matsuzaki, Y., Shibata, K., Kohike, H., Komori, T., Hayashi, M., Nakaki, T., Nakauchi, H., Okano, H., & Fujita, T. (2005). Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. Biochemical and Biophysical Research Communications, 328(1), 288-291. https://doi.org/10.1016/j.bbrc.2004.12.167

Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. / Hishikawa, Keiichi; Marumo, Takeshi; Miura, Shigeki; Nakanishi, Asato; Matsuzaki, Yumi; Shibata, Katsunori; Kohike, Hiroko; Komori, Takuya; Hayashi, Matsuhiko; Nakaki, Toshio; Nakauchi, Hiromitsu; Okano, Hideyuki; Fujita, Toshiro.

In: Biochemical and Biophysical Research Communications, Vol. 328, No. 1, 04.03.2005, p. 288-291.

Research output: Contribution to journal › Article › peer-review

Hishikawa, K, Marumo, T, Miura, S, Nakanishi, A, Matsuzaki, Y, Shibata, K, Kohike, H, Komori, T, Hayashi, M, Nakaki, T, Nakauchi, H, Okano, H & Fujita, T 2005, 'Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16', Biochemical and Biophysical Research Communications, vol. 328, no. 1, pp. 288-291. https://doi.org/10.1016/j.bbrc.2004.12.167

Hishikawa, Keiichi ; Marumo, Takeshi ; Miura, Shigeki ; Nakanishi, Asato ; Matsuzaki, Yumi ; Shibata, Katsunori ; Kohike, Hiroko ; Komori, Takuya ; Hayashi, Matsuhiko ; Nakaki, Toshio ; Nakauchi, Hiromitsu ; Okano, Hideyuki ; Fujita, Toshiro. / Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. In: Biochemical and Biophysical Research Communications. 2005 ; Vol. 328, No. 1. pp. 288-291.

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abstract = "Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.",

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