Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Keiichi Hishikawa; Takeshi Marumo; Shigeki Miura; Asato Nakanishi; Yumi Matsuzaki; Katsunori Shibata; Hiroko Kohike; Takuya Komori; Matsuhiko Hayashi; Toshio Nakaki; Hiromitsu Nakauchi; Hideyuki Okano; Toshiro Fujita

doi:10.1016/j.bbrc.2004.12.167

Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Keiichi Hishikawa, Takeshi Marumo, Shigeki Miura, Asato Nakanishi, Yumi Matsuzaki, Katsunori Shibata, Hiroko Kohike, Takuya Komori, Matsuhiko Hayashi, Toshio Nakaki, Hiromitsu Nakauchi, Hideyuki Okano, Toshiro Fujita

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22 Citations (Scopus)

Abstract

Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.

Original language	English
Pages (from-to)	288-291
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	328
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2004.12.167
Publication status	Published - 2005 Mar 4

Keywords

Cadherin 16
Regenerative medicine
Stem cell

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.12.167

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Hishikawa, K., Marumo, T., Miura, S., Nakanishi, A., Matsuzaki, Y., Shibata, K., Kohike, H., Komori, T., Hayashi, M., Nakaki, T., Nakauchi, H., Okano, H., & Fujita, T. (2005). Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. Biochemical and Biophysical Research Communications, 328(1), 288-291. https://doi.org/10.1016/j.bbrc.2004.12.167

Hishikawa, K, Marumo, T, Miura, S, Nakanishi, A, Matsuzaki, Y, Shibata, K, Kohike, H, Komori, T, Hayashi, M, Nakaki, T, Nakauchi, H, Okano, H & Fujita, T 2005, 'Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16', Biochemical and Biophysical Research Communications, vol. 328, no. 1, pp. 288-291. https://doi.org/10.1016/j.bbrc.2004.12.167

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title = "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16",

abstract = "Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.",

keywords = "Cadherin 16, Regenerative medicine, Stem cell",

author = "Keiichi Hishikawa and Takeshi Marumo and Shigeki Miura and Asato Nakanishi and Yumi Matsuzaki and Katsunori Shibata and Hiroko Kohike and Takuya Komori and Matsuhiko Hayashi and Toshio Nakaki and Hiromitsu Nakauchi and Hideyuki Okano and Toshiro Fujita",

note = "Funding Information: This study was supported by a grant from the Open Competition for the Development of Innovative Technology and Mochida Pharmaceutical Co. Ltd.",

year = "2005",

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doi = "10.1016/j.bbrc.2004.12.167",

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AU - Hishikawa, Keiichi

AU - Marumo, Takeshi

AU - Miura, Shigeki

AU - Nakanishi, Asato

AU - Matsuzaki, Yumi

AU - Shibata, Katsunori

AU - Kohike, Hiroko

AU - Komori, Takuya

AU - Hayashi, Matsuhiko

AU - Nakaki, Toshio

AU - Nakauchi, Hiromitsu

AU - Okano, Hideyuki

AU - Fujita, Toshiro

N1 - Funding Information: This study was supported by a grant from the Open Competition for the Development of Innovative Technology and Mochida Pharmaceutical Co. Ltd.

PY - 2005/3/4

Y1 - 2005/3/4

N2 - Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.

AB - Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.

KW - Cadherin 16

KW - Regenerative medicine

KW - Stem cell

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Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Abstract

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