Abstract
Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.
Original language | English |
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Pages (from-to) | 288-291 |
Number of pages | 4 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 328 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2005 Mar 4 |
Keywords
- Cadherin 16
- Regenerative medicine
- Stem cell
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology