Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF

T. Inukai, K. Sugita, K. Iijima, K. Goi, T. Tezuka, S. Kojika, K. Kagami, T. Mori, A. Kinoshita, T. Suzuki, T. O-Koyama, S. Nakazawa

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24 Citations (Scopus)

Abstract

We report a 20-month-old boy with acute lymphoblastic leukemia with the 11q23 translocation whose blasts markedly increased in peripheral blood after intravenous granulocyte colony-stimulating factor (G-CSF) administration, but disappeared after stopping G-CSF. The in vitro study showed that the leukemic cells separated from this patient expressed G-CSF receptor (G-CSFR) and an addition of G-CSF stimulated their proliferation by 3H-thymidine incorporation assay (stimulation index, 4.9). To clarify whether or not leukemic cells with 11q23 translocations generally express G-CSFR and show proliferative response to G-CSF, we performed the similar in vitro experiments using eight leukemic cell lines with 11q23 translocations. We found that all cell lines examined expressed G-CSFR (20-98%) and proliferation of seven leukemic cell lines was significantly enhanced in response to G-CSF (stimulation index > 1.5 in five cell lines), suggesting a possible participation of the G-CSF/G-CSFR interaction in the process of growth regulation of leukemic cells with 11q23 translocations.

Original languageEnglish
Pages (from-to)382-389
Number of pages8
JournalLeukemia
Volume12
Issue number3
DOIs
Publication statusPublished - 1998 Jan 1

Keywords

  • 11q23 translocation
  • G-CSF
  • G-CSFR
  • Infant leukemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Inukai, T., Sugita, K., Iijima, K., Goi, K., Tezuka, T., Kojika, S., Kagami, K., Mori, T., Kinoshita, A., Suzuki, T., O-Koyama, T., & Nakazawa, S. (1998). Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF. Leukemia, 12(3), 382-389. https://doi.org/10.1038/sj.leu.2400951