Leukocyte subpopulations and natural killer activity in endometriosis

K. I. Iwasaki, T. Makino, T. Maruyama, H. Matsubayashi, S. Nozawa, T. Yokokura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective - To evaluate cell-mediated immunity in endometriosis. Design - Peritoneal fluid and peripheral blood samples from 19 women with macroscopic evidence of endometriosis and 26 controls were submitted to 2-color flow cytometric analysis to assess lymphocyte subsets, using various combinations of monoclonal antibodies. K562 cells were used in a routine assay by 51Cr release to measure the cytotoxicity of NK cells in the subjects' peripheral blood. Results - Suppressor T-cells were significantly increased and cytotoxic T-cells significantly decreased in both peritoneal fluid and peripheral blood of the women with endometriosis. NK activity in peripheral blood was decreased in endometriosis patients as compared with controls. Conclusion - An alteration in cell-mediated immunity may be among the pathogenetic, or developing, factors in endometriosis.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalInternational Journal of Fertility
Volume38
Issue number4
Publication statusPublished - 1993 Jan 1

Keywords

  • cell-mediated immunity
  • endometriosis
  • flow cytometric analysis
  • lymphocytes (NK-, T-cells)

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Iwasaki, K. I., Makino, T., Maruyama, T., Matsubayashi, H., Nozawa, S., & Yokokura, T. (1993). Leukocyte subpopulations and natural killer activity in endometriosis. International Journal of Fertility, 38(4), 229-234.