Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group

Hidemitsu Kurosawa, Akihiko Tanizawa, Chikako Tono, Akihiro Watanabe, Haruko Shima, Masaki Ito, Yuki Yuza, Noriko Hotta, Hideki Muramatsu, Masahiko Okada, Ryosuke Kajiwara, Akiko Moriya Saito, Shuki Mizutani, Souichi Adachi, Keizo Horibe, Eiichi Ishii, Hiroyuki Shimada

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The details of leukostasis in children and adolescents with chronic myeloid leukemia (CML) are unknown. This study determined the characteristics of leukostasis in children and adolescents with CML. Procedure: A total of 256 cases from a retrospective study of patients with CML conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group from 1996 to 2011 were analyzed, and of these, 238 cases were evaluated in this study. Results: Leukostasis was diagnosed in 23 patients (9.7%). The median leukocyte count and spleen size below the left costal margin in cases with leukostasis were significantly higher and larger when compared to those in cases without leukostasis (458.5 × 109/l vs. 151.8 × 109/l (P <0.01), and 13 vs. 5 cm (P <0.01), respectively). Leukostasis occurred with ocular symptoms in 14 cases, priapism in four cases, and dyspnea, syncope, headache, knee pain, difficulty hearing, and aseptic necrosis of the femoral head in one case each. One case had two leukostasis symptoms simultaneously. Three cases were diagnosed before imatinib became available. Five cases received special treatment, and in the remaining 15 cases, all of these symptoms resolved after treatment with imatinib. Conclusions: This retrospective study represents the largest series of children and adolescents in which leukostasis of CML has been reported. Our data provide useful insight into the characteristics of leukostasis in recent cases of children and adolescents with CML.

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalPediatric Blood and Cancer
Volume63
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Leukostasis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphoma
Leukemia
Pediatrics
Retrospective Studies
Priapism
Syncope
Thigh
Leukocyte Count
Dyspnea
Hearing
Headache
Knee
Necrosis
Spleen

Keywords

  • CML
  • Hyperleukocytosis
  • Imatinib
  • Leukostasis

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia : Japanese Pediatric Leukemia/Lymphoma Study Group. / Kurosawa, Hidemitsu; Tanizawa, Akihiko; Tono, Chikako; Watanabe, Akihiro; Shima, Haruko; Ito, Masaki; Yuza, Yuki; Hotta, Noriko; Muramatsu, Hideki; Okada, Masahiko; Kajiwara, Ryosuke; Moriya Saito, Akiko; Mizutani, Shuki; Adachi, Souichi; Horibe, Keizo; Ishii, Eiichi; Shimada, Hiroyuki.

In: Pediatric Blood and Cancer, Vol. 63, No. 3, 01.03.2016, p. 406-411.

Research output: Contribution to journalArticle

Kurosawa, H, Tanizawa, A, Tono, C, Watanabe, A, Shima, H, Ito, M, Yuza, Y, Hotta, N, Muramatsu, H, Okada, M, Kajiwara, R, Moriya Saito, A, Mizutani, S, Adachi, S, Horibe, K, Ishii, E & Shimada, H 2016, 'Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group', Pediatric Blood and Cancer, vol. 63, no. 3, pp. 406-411. https://doi.org/10.1002/pbc.25803
Kurosawa, Hidemitsu ; Tanizawa, Akihiko ; Tono, Chikako ; Watanabe, Akihiro ; Shima, Haruko ; Ito, Masaki ; Yuza, Yuki ; Hotta, Noriko ; Muramatsu, Hideki ; Okada, Masahiko ; Kajiwara, Ryosuke ; Moriya Saito, Akiko ; Mizutani, Shuki ; Adachi, Souichi ; Horibe, Keizo ; Ishii, Eiichi ; Shimada, Hiroyuki. / Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia : Japanese Pediatric Leukemia/Lymphoma Study Group. In: Pediatric Blood and Cancer. 2016 ; Vol. 63, No. 3. pp. 406-411.
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abstract = "Background: The details of leukostasis in children and adolescents with chronic myeloid leukemia (CML) are unknown. This study determined the characteristics of leukostasis in children and adolescents with CML. Procedure: A total of 256 cases from a retrospective study of patients with CML conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group from 1996 to 2011 were analyzed, and of these, 238 cases were evaluated in this study. Results: Leukostasis was diagnosed in 23 patients (9.7{\%}). The median leukocyte count and spleen size below the left costal margin in cases with leukostasis were significantly higher and larger when compared to those in cases without leukostasis (458.5 × 109/l vs. 151.8 × 109/l (P <0.01), and 13 vs. 5 cm (P <0.01), respectively). Leukostasis occurred with ocular symptoms in 14 cases, priapism in four cases, and dyspnea, syncope, headache, knee pain, difficulty hearing, and aseptic necrosis of the femoral head in one case each. One case had two leukostasis symptoms simultaneously. Three cases were diagnosed before imatinib became available. Five cases received special treatment, and in the remaining 15 cases, all of these symptoms resolved after treatment with imatinib. Conclusions: This retrospective study represents the largest series of children and adolescents in which leukostasis of CML has been reported. Our data provide useful insight into the characteristics of leukostasis in recent cases of children and adolescents with CML.",
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T1 - Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia

T2 - Japanese Pediatric Leukemia/Lymphoma Study Group

AU - Kurosawa, Hidemitsu

AU - Tanizawa, Akihiko

AU - Tono, Chikako

AU - Watanabe, Akihiro

AU - Shima, Haruko

AU - Ito, Masaki

AU - Yuza, Yuki

AU - Hotta, Noriko

AU - Muramatsu, Hideki

AU - Okada, Masahiko

AU - Kajiwara, Ryosuke

AU - Moriya Saito, Akiko

AU - Mizutani, Shuki

AU - Adachi, Souichi

AU - Horibe, Keizo

AU - Ishii, Eiichi

AU - Shimada, Hiroyuki

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: The details of leukostasis in children and adolescents with chronic myeloid leukemia (CML) are unknown. This study determined the characteristics of leukostasis in children and adolescents with CML. Procedure: A total of 256 cases from a retrospective study of patients with CML conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group from 1996 to 2011 were analyzed, and of these, 238 cases were evaluated in this study. Results: Leukostasis was diagnosed in 23 patients (9.7%). The median leukocyte count and spleen size below the left costal margin in cases with leukostasis were significantly higher and larger when compared to those in cases without leukostasis (458.5 × 109/l vs. 151.8 × 109/l (P <0.01), and 13 vs. 5 cm (P <0.01), respectively). Leukostasis occurred with ocular symptoms in 14 cases, priapism in four cases, and dyspnea, syncope, headache, knee pain, difficulty hearing, and aseptic necrosis of the femoral head in one case each. One case had two leukostasis symptoms simultaneously. Three cases were diagnosed before imatinib became available. Five cases received special treatment, and in the remaining 15 cases, all of these symptoms resolved after treatment with imatinib. Conclusions: This retrospective study represents the largest series of children and adolescents in which leukostasis of CML has been reported. Our data provide useful insight into the characteristics of leukostasis in recent cases of children and adolescents with CML.

AB - Background: The details of leukostasis in children and adolescents with chronic myeloid leukemia (CML) are unknown. This study determined the characteristics of leukostasis in children and adolescents with CML. Procedure: A total of 256 cases from a retrospective study of patients with CML conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group from 1996 to 2011 were analyzed, and of these, 238 cases were evaluated in this study. Results: Leukostasis was diagnosed in 23 patients (9.7%). The median leukocyte count and spleen size below the left costal margin in cases with leukostasis were significantly higher and larger when compared to those in cases without leukostasis (458.5 × 109/l vs. 151.8 × 109/l (P <0.01), and 13 vs. 5 cm (P <0.01), respectively). Leukostasis occurred with ocular symptoms in 14 cases, priapism in four cases, and dyspnea, syncope, headache, knee pain, difficulty hearing, and aseptic necrosis of the femoral head in one case each. One case had two leukostasis symptoms simultaneously. Three cases were diagnosed before imatinib became available. Five cases received special treatment, and in the remaining 15 cases, all of these symptoms resolved after treatment with imatinib. Conclusions: This retrospective study represents the largest series of children and adolescents in which leukostasis of CML has been reported. Our data provide useful insight into the characteristics of leukostasis in recent cases of children and adolescents with CML.

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KW - Hyperleukocytosis

KW - Imatinib

KW - Leukostasis

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