TY - JOUR
T1 - Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia
T2 - Japanese Pediatric Leukemia/Lymphoma Study Group
AU - Kurosawa, Hidemitsu
AU - Tanizawa, Akihiko
AU - Tono, Chikako
AU - Watanabe, Akihiro
AU - Shima, Haruko
AU - Ito, Masaki
AU - Yuza, Yuki
AU - Hotta, Noriko
AU - Muramatsu, Hideki
AU - Okada, Masahiko
AU - Kajiwara, Ryosuke
AU - Moriya Saito, Akiko
AU - Mizutani, Shuki
AU - Adachi, Souichi
AU - Horibe, Keizo
AU - Ishii, Eiichi
AU - Shimada, Hiroyuki
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background: The details of leukostasis in children and adolescents with chronic myeloid leukemia (CML) are unknown. This study determined the characteristics of leukostasis in children and adolescents with CML. Procedure: A total of 256 cases from a retrospective study of patients with CML conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group from 1996 to 2011 were analyzed, and of these, 238 cases were evaluated in this study. Results: Leukostasis was diagnosed in 23 patients (9.7%). The median leukocyte count and spleen size below the left costal margin in cases with leukostasis were significantly higher and larger when compared to those in cases without leukostasis (458.5 × 109/l vs. 151.8 × 109/l (P < 0.01), and 13 vs. 5 cm (P < 0.01), respectively). Leukostasis occurred with ocular symptoms in 14 cases, priapism in four cases, and dyspnea, syncope, headache, knee pain, difficulty hearing, and aseptic necrosis of the femoral head in one case each. One case had two leukostasis symptoms simultaneously. Three cases were diagnosed before imatinib became available. Five cases received special treatment, and in the remaining 15 cases, all of these symptoms resolved after treatment with imatinib. Conclusions: This retrospective study represents the largest series of children and adolescents in which leukostasis of CML has been reported. Our data provide useful insight into the characteristics of leukostasis in recent cases of children and adolescents with CML.
AB - Background: The details of leukostasis in children and adolescents with chronic myeloid leukemia (CML) are unknown. This study determined the characteristics of leukostasis in children and adolescents with CML. Procedure: A total of 256 cases from a retrospective study of patients with CML conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group from 1996 to 2011 were analyzed, and of these, 238 cases were evaluated in this study. Results: Leukostasis was diagnosed in 23 patients (9.7%). The median leukocyte count and spleen size below the left costal margin in cases with leukostasis were significantly higher and larger when compared to those in cases without leukostasis (458.5 × 109/l vs. 151.8 × 109/l (P < 0.01), and 13 vs. 5 cm (P < 0.01), respectively). Leukostasis occurred with ocular symptoms in 14 cases, priapism in four cases, and dyspnea, syncope, headache, knee pain, difficulty hearing, and aseptic necrosis of the femoral head in one case each. One case had two leukostasis symptoms simultaneously. Three cases were diagnosed before imatinib became available. Five cases received special treatment, and in the remaining 15 cases, all of these symptoms resolved after treatment with imatinib. Conclusions: This retrospective study represents the largest series of children and adolescents in which leukostasis of CML has been reported. Our data provide useful insight into the characteristics of leukostasis in recent cases of children and adolescents with CML.
KW - CML
KW - Hyperleukocytosis
KW - Imatinib
KW - Leukostasis
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U2 - 10.1002/pbc.25803
DO - 10.1002/pbc.25803
M3 - Article
C2 - 26485422
AN - SCOPUS:84969425021
SN - 1545-5009
VL - 63
SP - 406
EP - 411
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 3
ER -