Leumorphin is a potent inhibitor of vasopressin secretion.

T. Yamada, K. Nakao, H. Itoh, N. Morii, S. Shiono, M. Sakamoto, A. Sugawara, Y. Saito, G. Katsuura, M. Eigyo

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1 Citation (Scopus)

Abstract

The effects of intracerebroventricular (i.c.v.) injection of leumorphin on the vasopressin secretion induced by angiotensin II or dehydration were studied in conscious unrestrained rats. The vasopressin secretion induced by angiotensin II (100 pmol) was significantly inhibited by the simultaneous injection of leumorphin (6 pmol-600 pmol) in a dose-dependent manner. In 72-hour water-deprived rats, the i.c.v. injection of leumorphin (60 pmol or 600 pmol) significantly suppressed the vasopressin secretion dose-dependently. These results suggest that leumorphin is involved in the regulation of the vasopressin secretion.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalNIDA research monograph
Volume75
Publication statusPublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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