Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Kota Asai, Takuya Togashi, Eiji Okada

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

    Original languageEnglish
    Title of host publicationBiomedical Imaging and Sensing Conference
    PublisherSPIE
    Volume10251
    ISBN (Electronic)9781510610033
    DOIs
    Publication statusPublished - 2017
    Event3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan
    Duration: 2017 Apr 192017 Apr 21

    Other

    Other3rd Biomedical Imaging and Sensing Conference
    CountryJapan
    CityYokohama
    Period17/4/1917/4/21

    Keywords

    • Fluorescence Measurement
    • Light Propagation
    • Optical Diagnosis

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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  • Cite this

    Asai, K., Togashi, T., & Okada, E. (2017). Light propagation analysis for fluorescence measurements of a molecular probe in the brain. In Biomedical Imaging and Sensing Conference (Vol. 10251). [102511S] SPIE. https://doi.org/10.1117/12.2274896