Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Kota Asai; Takuya Togashi; Eiji Okada

doi:10.1117/12.2274896

Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Kota Asai, Takuya Togashi, Eiji Okada

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference
Publisher	SPIE
Volume	10251
ISBN (Electronic)	9781510610033
DOIs	https://doi.org/10.1117/12.2274896
Publication status	Published - 2017
Event	3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan Duration: 2017 Apr 19 → 2017 Apr 21

Other

Other	3rd Biomedical Imaging and Sensing Conference
Country/Territory	Japan
City	Yokohama
Period	17/4/19 → 17/4/21

Keywords

Fluorescence Measurement
Light Propagation
Optical Diagnosis

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.2274896

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title = "Light propagation analysis for fluorescence measurements of a molecular probe in the brain",

abstract = "Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.",

keywords = "Fluorescence Measurement, Light Propagation, Optical Diagnosis",

author = "Kota Asai and Takuya Togashi and Eiji Okada",

year = "2017",

doi = "10.1117/12.2274896",

language = "English",

volume = "10251",

booktitle = "Biomedical Imaging and Sensing Conference",

publisher = "SPIE",

note = "3rd Biomedical Imaging and Sensing Conference ; Conference date: 19-04-2017 Through 21-04-2017",

}

TY - GEN

T1 - Light propagation analysis for fluorescence measurements of a molecular probe in the brain

AU - Asai, Kota

AU - Togashi, Takuya

AU - Okada, Eiji

PY - 2017

Y1 - 2017

N2 - Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

AB - Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

KW - Fluorescence Measurement

KW - Light Propagation

KW - Optical Diagnosis

UR - http://www.scopus.com/inward/record.url?scp=85023769863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023769863&partnerID=8YFLogxK

U2 - 10.1117/12.2274896

DO - 10.1117/12.2274896

M3 - Conference contribution

AN - SCOPUS:85023769863

VL - 10251

BT - Biomedical Imaging and Sensing Conference

PB - SPIE

T2 - 3rd Biomedical Imaging and Sensing Conference

Y2 - 19 April 2017 through 21 April 2017

ER -

Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Abstract

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Keywords

ASJC Scopus subject areas

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