LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

Takeyasu Tomioka, Takuya Shimazaki, Toshihiko Yamauchi, Toru Oki, Makoto Ohgoh, Hideyuki Okano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: LIM homeobox 8 (Lhx8) functions in the differentiation of cholinergic neurons. Results: Lhx8 regulates functions of cholinergic neurons by modulating tropomyosin receptor kinaseA(TrkA) expression. Lhx8 expression and function are regulated by NGF. Conclusion: Lhx8 is a mediator of NGF signaling for the regulation of cholinergic functions.

Original languageEnglish
Pages (from-to)1000-1010
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number2
DOIs
Publication statusPublished - 2014 Jan 10

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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