Abstract
Limbic encephalitis (LE) refers to an inflammatory disorder involving the hippocampus, amygdala and insular cortex. LE is now regarded as a more frequent disorder than it was previously thought, and the concept of LE has been expanded because of the development of neuroimaging and the increasing recognition of the associated antibodies. We categorized LE into 5 groups. LE caused by virus infection, autoantibody-mediated LE, LE with autoimmune disease, LE associated with drugs and LE during pregnancy. LE having the antibodies against intracellular antigens frequently related to cancer and are resistant to treatment. While, LE with antibodies against cell-membrane antigens, including NMDAR, AMPAR, GABA(B)R, VGKC, tend to respond better to antitumor therapy and immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 442-447 |
| Number of pages | 6 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 69 |
| Issue number | 3 |
| Publication status | Published - 2011 Mar |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
[Limbic encephalitis up to date]. / Seki, Morinobu; Suzuki, Shigeaki; Suzuki, Norihiro.
In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 69, No. 3, 03.2011, p. 442-447.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - [Limbic encephalitis up to date].
AU - Seki, Morinobu
AU - Suzuki, Shigeaki
AU - Suzuki, Norihiro
PY - 2011/3
Y1 - 2011/3
N2 - Limbic encephalitis (LE) refers to an inflammatory disorder involving the hippocampus, amygdala and insular cortex. LE is now regarded as a more frequent disorder than it was previously thought, and the concept of LE has been expanded because of the development of neuroimaging and the increasing recognition of the associated antibodies. We categorized LE into 5 groups. LE caused by virus infection, autoantibody-mediated LE, LE with autoimmune disease, LE associated with drugs and LE during pregnancy. LE having the antibodies against intracellular antigens frequently related to cancer and are resistant to treatment. While, LE with antibodies against cell-membrane antigens, including NMDAR, AMPAR, GABA(B)R, VGKC, tend to respond better to antitumor therapy and immunotherapy.
AB - Limbic encephalitis (LE) refers to an inflammatory disorder involving the hippocampus, amygdala and insular cortex. LE is now regarded as a more frequent disorder than it was previously thought, and the concept of LE has been expanded because of the development of neuroimaging and the increasing recognition of the associated antibodies. We categorized LE into 5 groups. LE caused by virus infection, autoantibody-mediated LE, LE with autoimmune disease, LE associated with drugs and LE during pregnancy. LE having the antibodies against intracellular antigens frequently related to cancer and are resistant to treatment. While, LE with antibodies against cell-membrane antigens, including NMDAR, AMPAR, GABA(B)R, VGKC, tend to respond better to antitumor therapy and immunotherapy.
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M3 - Article
VL - 69
SP - 442
EP - 447
JO - Nihon rinsho. Japanese journal of clinical medicine
JF - Nihon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 3
ER -