Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery

A review

Keiju Aokage, Junji Yoshida, Tomoyuki Hishida, Masahiro Tsuboi, Hisashi Saji, Morihito Okada, Kenji Suzuki, Syunichi Watanabe, Hisao Asamura

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Since 'radical lobectomy' was reported by Cahan in 1960, the standard surgical care for lung cancer has been lobectomy, in which units of the lobe are excised with their specific regional hilar and mediastinal lymphatics. However, pulmonary function-preserving limited resection for lung cancer has gradually become more prevalent in the late 20th century. In 1995, Ginsberg et al. conducted a randomized controlled trial in which limited resection (segmentectomy and wide-wedge resection) and lobectomy for stage I lung cancer were compared and reported that limited resection should not be applied to healthy patients with clinical stage IA lung cancer. The detection of small-sized and early-stage lung cancers has improved with advancement in diagnostic technology. Ground-glass opacity of lung nodules, as recognized on thin-slice computed tomography, has also been widely recognized as being correlated with less-invasive pathological findings of alveolar epithelial cell replacement of cancer cells. The Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group conducted a cohort study of early peripheral lung cancer and investigated the validity thin-slice computed tomography criteria to diagnose non-invasive lung adenocarcinoma for the preoperative prediction of pathological non-invasive cancer. Following this observational study, the on-going JCOG0802/WJOG4607L, JCOG0804/WJOG4507L and JCOG1211 trials were initiated to confirm the validity of limited resection for stage I lung cancer patients stratified according to preoperative thin-slice computed tomography findings; these trials will clarify whether limited resection for lung cancer is not function-preserving but also only curative surgery.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume47
Issue number1
DOIs
Publication statusPublished - 2017

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Non-Small Cell Lung Carcinoma
Lung Neoplasms
Tomography
Alveolar Epithelial Cells
Lung
Medical Oncology
Segmental Mastectomy
Observational Studies
Glass
Neoplasms
Japan
Cohort Studies
Randomized Controlled Trials
Technology

Keywords

  • Ground glass nodule
  • Limited resection
  • Non-small cell lung cancer
  • Segmentectomy
  • Thinslice computed tomography
  • Wide-wedge resection

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery : A review. / Aokage, Keiju; Yoshida, Junji; Hishida, Tomoyuki; Tsuboi, Masahiro; Saji, Hisashi; Okada, Morihito; Suzuki, Kenji; Watanabe, Syunichi; Asamura, Hisao.

In: Japanese Journal of Clinical Oncology, Vol. 47, No. 1, 2017, p. 7-11.

Research output: Contribution to journalReview article

Aokage, Keiju ; Yoshida, Junji ; Hishida, Tomoyuki ; Tsuboi, Masahiro ; Saji, Hisashi ; Okada, Morihito ; Suzuki, Kenji ; Watanabe, Syunichi ; Asamura, Hisao. / Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery : A review. In: Japanese Journal of Clinical Oncology. 2017 ; Vol. 47, No. 1. pp. 7-11.
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