Line scan imaging of brain metabolites with CPMG sequences at 1.5 Tesla

Robert V. Mulkern, Jiqun Meng, Koichi Oshio, A. Aria Tzika

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A line scan Carr-Purcell-Meiboom-Gill (CPMG) spectroscopic imaging sequence has been implemented on a standard 1.5 T clinical scanner to map metabolite signals at multiple echo times from voxels along selected tissue columns through the brain. The CPMG multi-echo spectroscopic image data sets are used to estimate brain metabolite T2 decay parameters in a group of healthy volunteers and in one tumor patient. Inherent trade-offs between T2 decay, spectral resolution, and echo spacing prove to be important limiting factors. In particular, separate quantitation of choline and creatine resonances at 1.5 T was not achieved in the present implementation. However, the ability to collect data sets suitable for T2 decay analyses of combined choline and creatine resonances and N-acetyl aspartate resonances in under 10 minutes may prove of clinical utility in the study of brain pathology.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume6
Issue number2
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

Keywords

  • Brain metabolites
  • CPMG
  • Quantitation
  • Spectroscopic imaging
  • T2 decay

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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