Line scan imaging of brain metabolites with CPMG sequences at 1.5 Tesla

Robert V. Mulkern, Jiqun Meng, Koichi Oshio, A. Aria Tzika

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A line scan Carr-Purcell-Meiboom-Gill (CPMG) spectroscopic imaging sequence has been implemented on a standard 1.5 T clinical scanner to map metabolite signals at multiple echo times from voxels along selected tissue columns through the brain. The CPMG multi-echo spectroscopic image data sets are used to estimate brain metabolite T2 decay parameters in a group of healthy volunteers and in one tumor patient. Inherent trade-offs between T2 decay, spectral resolution, and echo spacing prove to be important limiting factors. In particular, separate quantitation of choline and creatine resonances at 1.5 T was not achieved in the present implementation. However, the ability to collect data sets suitable for T2 decay analyses of combined choline and creatine resonances and N-acetyl aspartate resonances in under 10 minutes may prove of clinical utility in the study of brain pathology.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume6
Issue number2
Publication statusPublished - 1996 Mar
Externally publishedYes

Fingerprint

Neuroimaging
Creatine
Choline
Brain
Healthy Volunteers
Pathology
Neoplasms
Datasets
N-acetylaspartate

Keywords

  • Brain metabolites
  • CPMG
  • Quantitation
  • Spectroscopic imaging
  • T2 decay

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Line scan imaging of brain metabolites with CPMG sequences at 1.5 Tesla. / Mulkern, Robert V.; Meng, Jiqun; Oshio, Koichi; Aria Tzika, A.

In: Journal of Magnetic Resonance Imaging, Vol. 6, No. 2, 03.1996, p. 399-405.

Research output: Contribution to journalArticle

Mulkern, Robert V. ; Meng, Jiqun ; Oshio, Koichi ; Aria Tzika, A. / Line scan imaging of brain metabolites with CPMG sequences at 1.5 Tesla. In: Journal of Magnetic Resonance Imaging. 1996 ; Vol. 6, No. 2. pp. 399-405.
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