Linoleic acid, other fatty acids, and the risk of stroke

Hiroyasu Iso, Shinichi Sato, Utako Umemura, Minako Kudo, Kazuko Koike, Akihiko Kitamura, Hironori Imano, Tomonori Okamura, Yoshihiko Naito, Takashi Shimamoto

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Background and Purpose - The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown. Methods -A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples from 7450 participants in cardiovascular risk surveys collected from 1984 to 1989 for 1 community and 1989 to 1992 for the other 2 communities. By the end of 1998, we identified 197 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage, and fasting status. Results - Compared with controls, total (n=197), hemorrhagic (n=75), and ischemic (n=122) strokes had similar proportions of n3 polyunsaturated fatty acids, lower proportions of linoleic and arachidonic acids, and higher proportions of saturated and monosaturated acids, determined by gas chromatography. The multivariate odds ratios associated with a 1-SD increase in linoleic acid (5%) after adjustment for hypertension, diabetes, serum total cholesterol, and other cardiovascular risk factors were 0.72 [95% confidence interval (CI), 0.59 to 0.89] for total stroke, 0.66 (95% CI, 0.49 to 0.88) for ischemic stroke, 0.63 (95% CI, 0.46 to 0.88) for lacunar infarction, and 0.81 (95% CI, 0.59 to 1.12) for hemorrhagic stroke. The respective odds ratios for saturated fatty acids (4%) were 1.13 (95% CI, 1.05 to 1.65), 1.35 (95% CI, 1.01 to 1.79), 1.44 (95% CI, 1.03 to 2.01), and 1.21 (95% CI, 0.82 to 1.80). Further adjustment for other fatty acids attenuated these relations, but the relation between linoleic acid and risk of ischemic stroke remained statistically significant. Conclusions - A higher intake of linoleic acid may protect against ischemic stroke, possibly through potential mechanisms of decreased blood pressure, reduced platelet aggregation, and enhanced deformability of erythrocyte cells.

Original languageEnglish
Pages (from-to)2086-2093
Number of pages8
JournalStroke
Volume33
Issue number8
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Linoleic Acid
Fatty Acids
Stroke
Confidence Intervals
Serum
Odds Ratio
Erythrocyte Deformability
Linoleic Acids
Arachidonic Acids
Lacunar Stroke
Omega-3 Fatty Acids
Platelet Aggregation
Gas Chromatography
Case-Control Studies
Fasting
Cholesterol
Blood Pressure
Hypertension
Acids

Keywords

  • Fatty acids
  • Fatty acids, unsaturated
  • Follow-up studies
  • Linoleic acid
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Iso, H., Sato, S., Umemura, U., Kudo, M., Koike, K., Kitamura, A., ... Shimamoto, T. (2002). Linoleic acid, other fatty acids, and the risk of stroke. Stroke, 33(8), 2086-2093. https://doi.org/10.1161/01.STR.0000023890.25066.50

Linoleic acid, other fatty acids, and the risk of stroke. / Iso, Hiroyasu; Sato, Shinichi; Umemura, Utako; Kudo, Minako; Koike, Kazuko; Kitamura, Akihiko; Imano, Hironori; Okamura, Tomonori; Naito, Yoshihiko; Shimamoto, Takashi.

In: Stroke, Vol. 33, No. 8, 2002, p. 2086-2093.

Research output: Contribution to journalArticle

Iso, H, Sato, S, Umemura, U, Kudo, M, Koike, K, Kitamura, A, Imano, H, Okamura, T, Naito, Y & Shimamoto, T 2002, 'Linoleic acid, other fatty acids, and the risk of stroke', Stroke, vol. 33, no. 8, pp. 2086-2093. https://doi.org/10.1161/01.STR.0000023890.25066.50
Iso H, Sato S, Umemura U, Kudo M, Koike K, Kitamura A et al. Linoleic acid, other fatty acids, and the risk of stroke. Stroke. 2002;33(8):2086-2093. https://doi.org/10.1161/01.STR.0000023890.25066.50
Iso, Hiroyasu ; Sato, Shinichi ; Umemura, Utako ; Kudo, Minako ; Koike, Kazuko ; Kitamura, Akihiko ; Imano, Hironori ; Okamura, Tomonori ; Naito, Yoshihiko ; Shimamoto, Takashi. / Linoleic acid, other fatty acids, and the risk of stroke. In: Stroke. 2002 ; Vol. 33, No. 8. pp. 2086-2093.
@article{9b384ea8f64a4487a4ac2dabf1228c39,
title = "Linoleic acid, other fatty acids, and the risk of stroke",
abstract = "Background and Purpose - The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown. Methods -A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples from 7450 participants in cardiovascular risk surveys collected from 1984 to 1989 for 1 community and 1989 to 1992 for the other 2 communities. By the end of 1998, we identified 197 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage, and fasting status. Results - Compared with controls, total (n=197), hemorrhagic (n=75), and ischemic (n=122) strokes had similar proportions of n3 polyunsaturated fatty acids, lower proportions of linoleic and arachidonic acids, and higher proportions of saturated and monosaturated acids, determined by gas chromatography. The multivariate odds ratios associated with a 1-SD increase in linoleic acid (5{\%}) after adjustment for hypertension, diabetes, serum total cholesterol, and other cardiovascular risk factors were 0.72 [95{\%} confidence interval (CI), 0.59 to 0.89] for total stroke, 0.66 (95{\%} CI, 0.49 to 0.88) for ischemic stroke, 0.63 (95{\%} CI, 0.46 to 0.88) for lacunar infarction, and 0.81 (95{\%} CI, 0.59 to 1.12) for hemorrhagic stroke. The respective odds ratios for saturated fatty acids (4{\%}) were 1.13 (95{\%} CI, 1.05 to 1.65), 1.35 (95{\%} CI, 1.01 to 1.79), 1.44 (95{\%} CI, 1.03 to 2.01), and 1.21 (95{\%} CI, 0.82 to 1.80). Further adjustment for other fatty acids attenuated these relations, but the relation between linoleic acid and risk of ischemic stroke remained statistically significant. Conclusions - A higher intake of linoleic acid may protect against ischemic stroke, possibly through potential mechanisms of decreased blood pressure, reduced platelet aggregation, and enhanced deformability of erythrocyte cells.",
keywords = "Fatty acids, Fatty acids, unsaturated, Follow-up studies, Linoleic acid, Stroke",
author = "Hiroyasu Iso and Shinichi Sato and Utako Umemura and Minako Kudo and Kazuko Koike and Akihiko Kitamura and Hironori Imano and Tomonori Okamura and Yoshihiko Naito and Takashi Shimamoto",
year = "2002",
doi = "10.1161/01.STR.0000023890.25066.50",
language = "English",
volume = "33",
pages = "2086--2093",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Linoleic acid, other fatty acids, and the risk of stroke

AU - Iso, Hiroyasu

AU - Sato, Shinichi

AU - Umemura, Utako

AU - Kudo, Minako

AU - Koike, Kazuko

AU - Kitamura, Akihiko

AU - Imano, Hironori

AU - Okamura, Tomonori

AU - Naito, Yoshihiko

AU - Shimamoto, Takashi

PY - 2002

Y1 - 2002

N2 - Background and Purpose - The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown. Methods -A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples from 7450 participants in cardiovascular risk surveys collected from 1984 to 1989 for 1 community and 1989 to 1992 for the other 2 communities. By the end of 1998, we identified 197 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage, and fasting status. Results - Compared with controls, total (n=197), hemorrhagic (n=75), and ischemic (n=122) strokes had similar proportions of n3 polyunsaturated fatty acids, lower proportions of linoleic and arachidonic acids, and higher proportions of saturated and monosaturated acids, determined by gas chromatography. The multivariate odds ratios associated with a 1-SD increase in linoleic acid (5%) after adjustment for hypertension, diabetes, serum total cholesterol, and other cardiovascular risk factors were 0.72 [95% confidence interval (CI), 0.59 to 0.89] for total stroke, 0.66 (95% CI, 0.49 to 0.88) for ischemic stroke, 0.63 (95% CI, 0.46 to 0.88) for lacunar infarction, and 0.81 (95% CI, 0.59 to 1.12) for hemorrhagic stroke. The respective odds ratios for saturated fatty acids (4%) were 1.13 (95% CI, 1.05 to 1.65), 1.35 (95% CI, 1.01 to 1.79), 1.44 (95% CI, 1.03 to 2.01), and 1.21 (95% CI, 0.82 to 1.80). Further adjustment for other fatty acids attenuated these relations, but the relation between linoleic acid and risk of ischemic stroke remained statistically significant. Conclusions - A higher intake of linoleic acid may protect against ischemic stroke, possibly through potential mechanisms of decreased blood pressure, reduced platelet aggregation, and enhanced deformability of erythrocyte cells.

AB - Background and Purpose - The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown. Methods -A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples from 7450 participants in cardiovascular risk surveys collected from 1984 to 1989 for 1 community and 1989 to 1992 for the other 2 communities. By the end of 1998, we identified 197 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage, and fasting status. Results - Compared with controls, total (n=197), hemorrhagic (n=75), and ischemic (n=122) strokes had similar proportions of n3 polyunsaturated fatty acids, lower proportions of linoleic and arachidonic acids, and higher proportions of saturated and monosaturated acids, determined by gas chromatography. The multivariate odds ratios associated with a 1-SD increase in linoleic acid (5%) after adjustment for hypertension, diabetes, serum total cholesterol, and other cardiovascular risk factors were 0.72 [95% confidence interval (CI), 0.59 to 0.89] for total stroke, 0.66 (95% CI, 0.49 to 0.88) for ischemic stroke, 0.63 (95% CI, 0.46 to 0.88) for lacunar infarction, and 0.81 (95% CI, 0.59 to 1.12) for hemorrhagic stroke. The respective odds ratios for saturated fatty acids (4%) were 1.13 (95% CI, 1.05 to 1.65), 1.35 (95% CI, 1.01 to 1.79), 1.44 (95% CI, 1.03 to 2.01), and 1.21 (95% CI, 0.82 to 1.80). Further adjustment for other fatty acids attenuated these relations, but the relation between linoleic acid and risk of ischemic stroke remained statistically significant. Conclusions - A higher intake of linoleic acid may protect against ischemic stroke, possibly through potential mechanisms of decreased blood pressure, reduced platelet aggregation, and enhanced deformability of erythrocyte cells.

KW - Fatty acids

KW - Fatty acids, unsaturated

KW - Follow-up studies

KW - Linoleic acid

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0036330004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036330004&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000023890.25066.50

DO - 10.1161/01.STR.0000023890.25066.50

M3 - Article

C2 - 12154268

AN - SCOPUS:0036330004

VL - 33

SP - 2086

EP - 2093

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 8

ER -