Lipase-catalyzed ring-opening polymerization of β-butyrolactone to the cyclic and linear poly(3-hydroxybutyrate)

Shuichi Matsumura, Yoichi Suzuki, Keisuke Tsukada, Kazunobu Toshima, Yoshiharu Doi, Ken Ichi Kasuya

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Abstract

The four-membered β-butyrolactone (BL) was polymerized using a ring-opening polymerization reaction with lipase as a catalyst at a temperature between 60 and 100 °C to yield the corresponding cyclic and linear poly(3-hydroxybutyrate)s [P(3HB)] with weight-average molecular weights of up to 7300. Among the tested lipases, porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CC) showed the best results with respect to the molecular weight of the resulting polymer and the monomer conversion. It was found that a significant amount of the cyclic P(3HB) fraction in the resulting polymer was produced and the cyclic polymer was increased with increasing monomer conversion. The (R)-BL was more easily polymerized by lipase to form the corresponding P(3HB) having a higher molecular weight than that formed by using (R,S)-BL.

Original languageEnglish
Pages (from-to)6444-6449
Number of pages6
JournalMacromolecules
Volume31
Issue number19
DOIs
Publication statusPublished - 1998 Sep 22

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ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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