Lipase-catalyzed transformation of poly(lactic acid) into cyclic oligomers

Yosuke Takahashi, Sachiko Okajima, Kazunobu Toshima, Shuichi Matsumura

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38 Citations (Scopus)

Abstract

Enzymatic transformations into cyclic oligomers were carried out with the objective of developing chemical recycling of poly(lactic acid)s, such as poly(D),L-lactic acid) (PDLLA), poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA), which are typical biodegradable polymers. They were degraded by lipase in an organic solvent to produce the corresponding cyclic oligomer with a molecular weight of several hundreds. PDLLA (with a M̄W of 84 000) was quantitatively transformed into cyclic oligomers by lipase RM (Lipozyme RM IM) in chloroform/hexane at 60 °C. PLLA (with a M̄R of 120 000) was transformed into cyclic oligomer by lipase CA (Novozym 435) at a higher temperature of 100 °C in o-xylene. The oligomer structure was identified by 1H and 13C NMR spectroscopy and MALDI-TOF (matrix assisted laser desorption/ionization-time-of-flight) mass spectrometry.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalMacromolecular Bioscience
Volume4
Issue number3
DOIs
Publication statusPublished - 2004 Mar 15

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Keywords

  • Degradation
  • Enzymes
  • Oligomers
  • Poly(lactic acid)
  • Recycling

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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