Lipase-mediated efficient preparation of both enantiomers of 2-acetoxytetracosanoic acid, the intermediate for sphingolipid synthesis

Takeshi Sugai, Hiromichi Ohta

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A solvent system of vinyl acetate-tetrahydrofuran at refluxing temperature was quite effective to perform enzymatic transesterification of highly crystalline substrate, such as 2-hydroxytetracosanoic acid a representative type of long-chain α-hydroxy acid. In that case, catalytic amount of di-t-butyl p-cresol (BHT) was essential as a polymerization inhibitor for vinyl acetate.

Original languageEnglish
Pages (from-to)7063-7064
Number of pages2
JournalTetrahedron Letters
Volume32
Issue number48
DOIs
Publication statusPublished - 1991 Nov 25

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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