Lipopeptides from Staphylococcus aureus as Tlr2 ligands: Prediction with mRNA expression, chemical synthesis, and immunostimulatory activities

Yukari Fujimoto, Masahito Hashimoto, Maiko Furuyashiki, Mami Katsumoto, Tsukasa Seya, Yasuo Suda, Koichi Fukase

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

(Chemical Equation Presented) Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences.

Original languageEnglish
Pages (from-to)2311-2315
Number of pages5
JournalChemBioChem
Volume10
Issue number14
DOIs
Publication statusPublished - 2009 Sep 21
Externally publishedYes

Keywords

  • Immunology
  • Lipoproteins
  • Staphylococcus aureus
  • Toll-like receptor 2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Lipopeptides from Staphylococcus aureus as Tlr2 ligands: Prediction with mRNA expression, chemical synthesis, and immunostimulatory activities'. Together they form a unique fingerprint.

Cite this