TY - JOUR
T1 - Lipopeptides from Staphylococcus aureus as Tlr2 ligands
T2 - Prediction with mRNA expression, chemical synthesis, and immunostimulatory activities
AU - Fujimoto, Yukari
AU - Hashimoto, Masahito
AU - Furuyashiki, Maiko
AU - Katsumoto, Mami
AU - Seya, Tsukasa
AU - Suda, Yasuo
AU - Fukase, Koichi
PY - 2009/9/21
Y1 - 2009/9/21
N2 - (Chemical Equation Presented) Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences.
AB - (Chemical Equation Presented) Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences.
KW - Immunology
KW - Lipoproteins
KW - Staphylococcus aureus
KW - Toll-like receptor 2
UR - http://www.scopus.com/inward/record.url?scp=70350539307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350539307&partnerID=8YFLogxK
U2 - 10.1002/cbic.200900242
DO - 10.1002/cbic.200900242
M3 - Article
C2 - 19681087
AN - SCOPUS:70350539307
SN - 1439-4227
VL - 10
SP - 2311
EP - 2315
JO - ChemBioChem
JF - ChemBioChem
IS - 14
ER -