Lipopeptides from Staphylococcus aureus as Tlr2 ligands: Prediction with mRNA expression, chemical synthesis, and immunostimulatory activities

Yukari Fujimoto, Masahito Hashimoto, Maiko Furuyashiki, Mami Katsumoto, Tsukasa Seya, Yasuo Suda, Koichi Fukase

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

(Chemical Equation Presented) Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences.

Original languageEnglish
Pages (from-to)2311-2315
Number of pages5
JournalChemBioChem
Volume10
Issue number14
DOIs
Publication statusPublished - 2009 Sep 21
Externally publishedYes

Keywords

  • Immunology
  • Lipoproteins
  • Staphylococcus aureus
  • Toll-like receptor 2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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