Lipopolysaccaride-induced neutrophilic inflammation in the lungs differs with age

Yoko Ito, Tomoko Betsuyaku, Yasuyuki Nasuhara, Masaharu Nishimura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-α, interleukin-1β, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrohilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury.

Original languageEnglish
Pages (from-to)375-384
Number of pages10
JournalExperimental Lung Research
Volume33
Issue number7
DOIs
Publication statusPublished - 2007 Sep
Externally publishedYes

Fingerprint

Lipopolysaccharides
Pneumonia
Chemokine CXCL2
Cytokines
Macrophage Inflammatory Proteins
Interleukin-1
Animals
Tumor Necrosis Factor-alpha
Acute Lung Injury
Lung Injury
Kinetics
Inflammation
Lung
keratinocyte-derived chemokines

Keywords

  • Acute lung injury
  • Age
  • IL-1β
  • LPS
  • TNF-α

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lipopolysaccaride-induced neutrophilic inflammation in the lungs differs with age. / Ito, Yoko; Betsuyaku, Tomoko; Nasuhara, Yasuyuki; Nishimura, Masaharu.

In: Experimental Lung Research, Vol. 33, No. 7, 09.2007, p. 375-384.

Research output: Contribution to journalArticle

Ito, Yoko ; Betsuyaku, Tomoko ; Nasuhara, Yasuyuki ; Nishimura, Masaharu. / Lipopolysaccaride-induced neutrophilic inflammation in the lungs differs with age. In: Experimental Lung Research. 2007 ; Vol. 33, No. 7. pp. 375-384.
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