Lipoprotein metabolism in Japanese centenarians

Effects of apolipoprotein E polymorphism and nutritional status

Yasumichi Arai, Nobuyoshi Hirose, Susumu Nakazawa, Ken Yamamura, Ken Ichirou Shimizu, Michiyo Takayama, Yoshinori Ebihara, Yasunori Osono, Satoki Homma

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

OBJECTIVES: To assess the complex interaction of apolipoprotein (apo) E polymorphisms and environmental factors on lipoprotein profile in centenarians. DESIGN: Cross-sectional analysis. SETTING: Tokyo metropolitan area. PARTICIPANTS: Seventy-five centenarians and 73 healthy older volunteers (mean age 63.1 ± 10.0) living in the Tokyo metropolitan area. MEASUREMENTS: Plasma lipids and lipoproteins, cholesteryl ester transfer protein mass, apo E phenotype, body mass index, nutritional indices (serum albumin, prealbumin, transferrin), dietary intake, inflammation markers (C-reactive protein (CRP), interleukin-6 (IL-6)), activities of daily living, and cognitive function. RESULTS: In comparison with older people, the centenarians had low concentrations of total and low-density lipoprotein cholesterol (LDL-C) and a relative predominance of high-density lipoprotein 2 cholesterol. No environmental factor, except the number of apo E ε2 alleles, was a significant determinant of LDL-C and apo B, suggesting that the low apo B-containing lipoprotein in centenarians may be attributable to a genetic cause. Centenarians had elevated levels of lipoprotein (a) and decreased high-density lipoprotein cholesterol (HDL-C), which seem to be an unfavorable lipoprotein profile. Lower levels of HDL-C in the centenarians were associated with decreased serum albumin, elevated CRP and IL-6 levels, and cognitive impairment, suggesting that HDL-C could be a sensitive marker for frailty and comorbidity in the oldest old. CONCLUSIONS: Low levels of apo B-containing lipoproteins attributable to a genetic cause may be advantageous for longevity. Lipoprotein profiles in centenarians were consistently related to the subjects' nutritional status, inflammation markers, and apo E polymorphisms. The results provide evidence for the importance of maintaining nutritional status in the very old.

Original languageEnglish
Pages (from-to)1434-1441
Number of pages8
JournalJournal of the American Geriatrics Society
Volume49
Issue number11
DOIs
Publication statusPublished - 2001

Fingerprint

Apolipoproteins E
Nutritional Status
Lipoproteins
HDL Cholesterol
Apolipoproteins B
Lipoprotein(a)
Tokyo
Serum Albumin
C-Reactive Protein
LDL Cholesterol
Interleukin-6
Apolipoprotein E2
HDL2 Lipoprotein
Cholesterol Ester Transfer Proteins
Inflammation
Nutrition Assessment
Prealbumin
Transferrin
Activities of Daily Living
Cognition

Keywords

  • Apo E polymorphism
  • Centenarians
  • Interleukin 6
  • Lipoprotein
  • Nutrition

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Lipoprotein metabolism in Japanese centenarians : Effects of apolipoprotein E polymorphism and nutritional status. / Arai, Yasumichi; Hirose, Nobuyoshi; Nakazawa, Susumu; Yamamura, Ken; Shimizu, Ken Ichirou; Takayama, Michiyo; Ebihara, Yoshinori; Osono, Yasunori; Homma, Satoki.

In: Journal of the American Geriatrics Society, Vol. 49, No. 11, 2001, p. 1434-1441.

Research output: Contribution to journalArticle

Arai, Yasumichi ; Hirose, Nobuyoshi ; Nakazawa, Susumu ; Yamamura, Ken ; Shimizu, Ken Ichirou ; Takayama, Michiyo ; Ebihara, Yoshinori ; Osono, Yasunori ; Homma, Satoki. / Lipoprotein metabolism in Japanese centenarians : Effects of apolipoprotein E polymorphism and nutritional status. In: Journal of the American Geriatrics Society. 2001 ; Vol. 49, No. 11. pp. 1434-1441.
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abstract = "OBJECTIVES: To assess the complex interaction of apolipoprotein (apo) E polymorphisms and environmental factors on lipoprotein profile in centenarians. DESIGN: Cross-sectional analysis. SETTING: Tokyo metropolitan area. PARTICIPANTS: Seventy-five centenarians and 73 healthy older volunteers (mean age 63.1 ± 10.0) living in the Tokyo metropolitan area. MEASUREMENTS: Plasma lipids and lipoproteins, cholesteryl ester transfer protein mass, apo E phenotype, body mass index, nutritional indices (serum albumin, prealbumin, transferrin), dietary intake, inflammation markers (C-reactive protein (CRP), interleukin-6 (IL-6)), activities of daily living, and cognitive function. RESULTS: In comparison with older people, the centenarians had low concentrations of total and low-density lipoprotein cholesterol (LDL-C) and a relative predominance of high-density lipoprotein 2 cholesterol. No environmental factor, except the number of apo E ε2 alleles, was a significant determinant of LDL-C and apo B, suggesting that the low apo B-containing lipoprotein in centenarians may be attributable to a genetic cause. Centenarians had elevated levels of lipoprotein (a) and decreased high-density lipoprotein cholesterol (HDL-C), which seem to be an unfavorable lipoprotein profile. Lower levels of HDL-C in the centenarians were associated with decreased serum albumin, elevated CRP and IL-6 levels, and cognitive impairment, suggesting that HDL-C could be a sensitive marker for frailty and comorbidity in the oldest old. CONCLUSIONS: Low levels of apo B-containing lipoproteins attributable to a genetic cause may be advantageous for longevity. Lipoprotein profiles in centenarians were consistently related to the subjects' nutritional status, inflammation markers, and apo E polymorphisms. The results provide evidence for the importance of maintaining nutritional status in the very old.",
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T1 - Lipoprotein metabolism in Japanese centenarians

T2 - Effects of apolipoprotein E polymorphism and nutritional status

AU - Arai, Yasumichi

AU - Hirose, Nobuyoshi

AU - Nakazawa, Susumu

AU - Yamamura, Ken

AU - Shimizu, Ken Ichirou

AU - Takayama, Michiyo

AU - Ebihara, Yoshinori

AU - Osono, Yasunori

AU - Homma, Satoki

PY - 2001

Y1 - 2001

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AB - OBJECTIVES: To assess the complex interaction of apolipoprotein (apo) E polymorphisms and environmental factors on lipoprotein profile in centenarians. DESIGN: Cross-sectional analysis. SETTING: Tokyo metropolitan area. PARTICIPANTS: Seventy-five centenarians and 73 healthy older volunteers (mean age 63.1 ± 10.0) living in the Tokyo metropolitan area. MEASUREMENTS: Plasma lipids and lipoproteins, cholesteryl ester transfer protein mass, apo E phenotype, body mass index, nutritional indices (serum albumin, prealbumin, transferrin), dietary intake, inflammation markers (C-reactive protein (CRP), interleukin-6 (IL-6)), activities of daily living, and cognitive function. RESULTS: In comparison with older people, the centenarians had low concentrations of total and low-density lipoprotein cholesterol (LDL-C) and a relative predominance of high-density lipoprotein 2 cholesterol. No environmental factor, except the number of apo E ε2 alleles, was a significant determinant of LDL-C and apo B, suggesting that the low apo B-containing lipoprotein in centenarians may be attributable to a genetic cause. Centenarians had elevated levels of lipoprotein (a) and decreased high-density lipoprotein cholesterol (HDL-C), which seem to be an unfavorable lipoprotein profile. Lower levels of HDL-C in the centenarians were associated with decreased serum albumin, elevated CRP and IL-6 levels, and cognitive impairment, suggesting that HDL-C could be a sensitive marker for frailty and comorbidity in the oldest old. CONCLUSIONS: Low levels of apo B-containing lipoproteins attributable to a genetic cause may be advantageous for longevity. Lipoprotein profiles in centenarians were consistently related to the subjects' nutritional status, inflammation markers, and apo E polymorphisms. The results provide evidence for the importance of maintaining nutritional status in the very old.

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KW - Interleukin 6

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