Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population

Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population. Methods and Results: We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC. Conclusions: In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalAtherosclerosis
Volume236
Issue number2
DOIs
Publication statusPublished - 2014 Jul 25

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Lipoproteins
Coronary Vessels
Magnetic Resonance Spectroscopy
HDL Cholesterol
Lipids
LDL Lipoproteins
LDL Cholesterol
HDL Lipoproteins
Cholesterol
Population
Odds Ratio
VLDL Lipoproteins
Particle Size
Triglycerides
Cardiovascular Diseases
Cross-Sectional Studies
Confidence Intervals
Serum

Keywords

  • Coronary artery calcification
  • Epidemiology
  • Lipids
  • Lipoproteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. / Hisamatsu, Takashi; Fujiyoshi, Akira; Miura, Katsuyuki; Ohkubo, Takayoshi; Kadota, Aya; Kadowaki, Sayaka; Kadowaki, Takashi; Yamamoto, Takashi; Miyagawa, Naoko; Zaid, Maryam; Torii, Sayuki; Takashima, Naoyuki; Murakami, Yoshitaka; Okamura, Tomonori; Horie, Minoru; Ueshima, Hirotsugu.

In: Atherosclerosis, Vol. 236, No. 2, 25.07.2014, p. 237-243.

Research output: Contribution to journalArticle

Hisamatsu, T, Fujiyoshi, A, Miura, K, Ohkubo, T, Kadota, A, Kadowaki, S, Kadowaki, T, Yamamoto, T, Miyagawa, N, Zaid, M, Torii, S, Takashima, N, Murakami, Y, Okamura, T, Horie, M & Ueshima, H 2014, 'Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population', Atherosclerosis, vol. 236, no. 2, pp. 237-243. https://doi.org/10.1016/j.atherosclerosis.2014.07.019
Hisamatsu, Takashi ; Fujiyoshi, Akira ; Miura, Katsuyuki ; Ohkubo, Takayoshi ; Kadota, Aya ; Kadowaki, Sayaka ; Kadowaki, Takashi ; Yamamoto, Takashi ; Miyagawa, Naoko ; Zaid, Maryam ; Torii, Sayuki ; Takashima, Naoyuki ; Murakami, Yoshitaka ; Okamura, Tomonori ; Horie, Minoru ; Ueshima, Hirotsugu. / Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. In: Atherosclerosis. 2014 ; Vol. 236, No. 2. pp. 237-243.
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T1 - Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population

AU - Hisamatsu, Takashi

AU - Fujiyoshi, Akira

AU - Miura, Katsuyuki

AU - Ohkubo, Takayoshi

AU - Kadota, Aya

AU - Kadowaki, Sayaka

AU - Kadowaki, Takashi

AU - Yamamoto, Takashi

AU - Miyagawa, Naoko

AU - Zaid, Maryam

AU - Torii, Sayuki

AU - Takashima, Naoyuki

AU - Murakami, Yoshitaka

AU - Okamura, Tomonori

AU - Horie, Minoru

AU - Ueshima, Hirotsugu

PY - 2014/7/25

Y1 - 2014/7/25

N2 - Objective: The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population. Methods and Results: We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC. Conclusions: In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids.

AB - Objective: The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population. Methods and Results: We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC. Conclusions: In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids.

KW - Coronary artery calcification

KW - Epidemiology

KW - Lipids

KW - Lipoproteins

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