Abstract
Synthetic heme was embedded in bilayers of liposome to produce a totally artificial oxygen-carrying substance. The in vivo oxygen-carrying capacity of this liposome-embedded heme (L/H) was studied in dogs. Dogs weighing 8 to 10 kg were anesthetized, intubated and mechanically ventilated with ambient air. A Swan-Ganz catheter and an arterial line were inserted for blood sampling and pressure monitoring. The hemoglobin (Hb) and L/H concentration in the blood were measured. After injection of L/H, cardiac output, Hb and L/H concentration in the blood were measured and oxygen transport by Hb and L/H, oxygen consumption from Hb and L/H, oxygen volume transported in the total oxygen transport, and oxygen volume consumed from L/H in the total oxygen consumption were calculated. It was found that L/H transported oxygen to the tissue, and that oxygen volume transported by L/H and oxygen volume consumed from L/H were proportional to L/H.
| Original language | English |
|---|---|
| Pages (from-to) | 412 |
| Number of pages | 1 |
| Journal | Biomaterials, Artificial Cells, and Immobilization Biotechnology |
| Volume | 19 |
| Issue number | 2 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Medicine(all)
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Liposome-embedded heme - totally synthetic oxygen carrier and its oxygen carrying capacity. / Kobayashi, Koichi; Watanabe, Masazumi; Ishihara, Tsuneo; Nishide, Hiroyuki; Tsuchida, Eisyun.
In: Biomaterials, Artificial Cells, and Immobilization Biotechnology, Vol. 19, No. 2, 1991, p. 412.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liposome-embedded heme - totally synthetic oxygen carrier and its oxygen carrying capacity
AU - Kobayashi, Koichi
AU - Watanabe, Masazumi
AU - Ishihara, Tsuneo
AU - Nishide, Hiroyuki
AU - Tsuchida, Eisyun
PY - 1991
Y1 - 1991
N2 - Synthetic heme was embedded in bilayers of liposome to produce a totally artificial oxygen-carrying substance. The in vivo oxygen-carrying capacity of this liposome-embedded heme (L/H) was studied in dogs. Dogs weighing 8 to 10 kg were anesthetized, intubated and mechanically ventilated with ambient air. A Swan-Ganz catheter and an arterial line were inserted for blood sampling and pressure monitoring. The hemoglobin (Hb) and L/H concentration in the blood were measured. After injection of L/H, cardiac output, Hb and L/H concentration in the blood were measured and oxygen transport by Hb and L/H, oxygen consumption from Hb and L/H, oxygen volume transported in the total oxygen transport, and oxygen volume consumed from L/H in the total oxygen consumption were calculated. It was found that L/H transported oxygen to the tissue, and that oxygen volume transported by L/H and oxygen volume consumed from L/H were proportional to L/H.
AB - Synthetic heme was embedded in bilayers of liposome to produce a totally artificial oxygen-carrying substance. The in vivo oxygen-carrying capacity of this liposome-embedded heme (L/H) was studied in dogs. Dogs weighing 8 to 10 kg were anesthetized, intubated and mechanically ventilated with ambient air. A Swan-Ganz catheter and an arterial line were inserted for blood sampling and pressure monitoring. The hemoglobin (Hb) and L/H concentration in the blood were measured. After injection of L/H, cardiac output, Hb and L/H concentration in the blood were measured and oxygen transport by Hb and L/H, oxygen consumption from Hb and L/H, oxygen volume transported in the total oxygen transport, and oxygen volume consumed from L/H in the total oxygen consumption were calculated. It was found that L/H transported oxygen to the tissue, and that oxygen volume transported by L/H and oxygen volume consumed from L/H were proportional to L/H.
UR - http://www.scopus.com/inward/record.url?scp=0026375684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026375684&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0026375684
VL - 19
SP - 412
JO - Artificial Cells, Nanomedicine and Biotechnology
JF - Artificial Cells, Nanomedicine and Biotechnology
SN - 2169-1401
IS - 2
ER -