TY - JOUR
T1 - Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma
AU - Kanazawa, Hideko
AU - Nagata, Yoshiko
AU - Matsushima, Yoshikazu
AU - Takai, Nobuharu
AU - Uchiyama, Hidefumi
AU - Nishimura, Ryohei
AU - Takeuchi, Akira
N1 - Funding Information:
This work was supportedi n part by the Science ResearchP romotion Fund of the Japan Private School Promotion Foundation.
PY - 1993/2/12
Y1 - 1993/2/12
N2 - A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.
AB - A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.
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U2 - 10.1016/0021-9673(93)80524-C
DO - 10.1016/0021-9673(93)80524-C
M3 - Article
C2 - 8450013
AN - SCOPUS:0027459157
SN - 0021-9673
VL - 631
SP - 215
EP - 220
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1-2
ER -