Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma

Hideko Kanazawa, Yoshiko Nagata, Yoshikazu Matsushima, Nobuharu Takai, Hidefumi Uchiyama, Ryohei Nishimura, Akira Takeuchi

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26 Citations (Scopus)

Abstract

A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalJournal of Chromatography A
Volume631
Issue number1-2
DOIs
Publication statusPublished - 1993 Feb 12

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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