Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma

Hideko Kanazawa, Yoshiko Itoh, Yoshikazu Matsushima, Nobuharu Takai, Hidefumi Uchiyama, Ryohei Nishimura, Akira Takeuchi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalJournal of Chromatography A
Volume631
Issue number1-2
DOIs
Publication statusPublished - 1993 Feb 12

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Medetomidine
Liquid chromatography
Liquid Chromatography
Mass spectrometry
Anesthetics
Mass Spectrometry
Butorphanol
Xylazine
Plasmas
Flumazenil
Atmospheric Pressure
Midazolam
Ketamine
Atropine
Atmospheric pressure
Ionization
Methanol
Dogs
Liquids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma. / Kanazawa, Hideko; Itoh, Yoshiko; Matsushima, Yoshikazu; Takai, Nobuharu; Uchiyama, Hidefumi; Nishimura, Ryohei; Takeuchi, Akira.

In: Journal of Chromatography A, Vol. 631, No. 1-2, 12.02.1993, p. 215-220.

Research output: Contribution to journalArticle

Kanazawa, Hideko ; Itoh, Yoshiko ; Matsushima, Yoshikazu ; Takai, Nobuharu ; Uchiyama, Hidefumi ; Nishimura, Ryohei ; Takeuchi, Akira. / Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma. In: Journal of Chromatography A. 1993 ; Vol. 631, No. 1-2. pp. 215-220.
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