Lithiation of 1,2-dichloroethene in flow microreactors: Versatile synthesis of alkenes and alkynes by precise residence-time control

Aiichiro Nagaki; Chika Matsuo; Songhee Kim; Kodai Saito; Atsuo Miyazaki; Jun Ichi Yoshida

doi:10.1002/anie.201108932

Lithiation of 1,2-dichloroethene in flow microreactors: Versatile synthesis of alkenes and alkynes by precise residence-time control

Aiichiro Nagaki, Chika Matsuo, Songhee Kim, Kodai Saito, Atsuo Miyazaki, Jun Ichi Yoshida

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

It′s all about the timing: Precise control of the residence time (t ^Rx; see picture) of reactive intermediates in flow microreactors enables the reaction pathway of lithiated 1,2-dichloroethene to be switched to produce either alkenes or alkynes. This method also allows versatile syntheses of asymmetric disubstituted dichloroalkenes and alkynes.

Original language	English
Pages (from-to)	3245-3248
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	13
DOIs	https://doi.org/10.1002/anie.201108932
Publication status	Published - 2012 Mar 26
Externally published	Yes

Keywords

alkenes
alkynes
lithiation
microreactors
synthetic methods

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201108932

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Lithiation of 1,2-dichloroethene in flow microreactors : Versatile synthesis of alkenes and alkynes by precise residence-time control. / Nagaki, Aiichiro; Matsuo, Chika; Kim, Songhee; Saito, Kodai; Miyazaki, Atsuo; Yoshida, Jun Ichi.

In: Angewandte Chemie - International Edition, Vol. 51, No. 13, 26.03.2012, p. 3245-3248.

Research output: Contribution to journal › Article › peer-review

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AU - Miyazaki, Atsuo

AU - Yoshida, Jun Ichi

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Lithiation of 1,2-dichloroethene in flow microreactors: Versatile synthesis of alkenes and alkynes by precise residence-time control

Abstract

Keywords

ASJC Scopus subject areas

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