Lithiation of 1,2-dichloroethene in flow microreactors: Versatile synthesis of alkenes and alkynes by precise residence-time control

Aiichiro Nagaki, Chika Matsuo, Songhee Kim, Kodai Saito, Atsuo Miyazaki, Jun Ichi Yoshida

Research output: Contribution to journalArticle

71 Citations (Scopus)


It′s all about the timing: Precise control of the residence time (t Rx; see picture) of reactive intermediates in flow microreactors enables the reaction pathway of lithiated 1,2-dichloroethene to be switched to produce either alkenes or alkynes. This method also allows versatile syntheses of asymmetric disubstituted dichloroalkenes and alkynes.

Original languageEnglish
Pages (from-to)3245-3248
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number13
Publication statusPublished - 2012 Mar 26



  • alkenes
  • alkynes
  • lithiation
  • microreactors
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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