@article{c558b545b9ff429cb34028e4a92b9fc5,
title = "Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila",
abstract = "Kosakamoto et al. report that wing necrosis induces dysbiotic expansion of Gluconobacter sp. in the gut, which leads to hyperactivation of innate immunity and mortality in Drosophila. This study highlights an interaction between the host and microbial factors triggering a pathological systemic inflammatory response against local necrosis.",
keywords = "Drosophila, Immune response, apoptosis, gluconobacter, gut microbiota, lifespan, metabolome, necrosis",
author = "Hina Kosakamoto and Toshitaka Yamauchi and Yoriko Akuzawa-Tokita and Kei Nishimura and Tomoyoshi Soga and Takumi Murakami and Hiroshi Mori and Kyosuke Yamamoto and Ryo Miyazaki and Akiko Koto and Masayuki Miura and Fumiaki Obata",
note = "Funding Information: We would like to acknowledge Ayame Enomoto, Kaori Saitoh, Keiko Kato, Aki Hori, Takayuki Kuraishi, Yuki Sugiura, and all Miura lab members for technical assistance and critical comments. We thank the Kyoto Stock Center and the Bloomington Drosophila Stock Center for fly stocks. This work was supported by Agency for Medical Research and Development (AMED)-PRIME to F.O. under grant 20gm6010010h0004, by AMED-CREST to H.M. under grant JP18gm1010006, and by AMED-Project for Elucidating and Controlling Mechanisms of Aging and Longevity to M.M. under grant JP20gm5010001. This work was also supported partly by grants from the Japan Society for the Promotion of Science to M.M. under grant 16H06385, from the Takeda Science Foundation to F.O. and from the Mochida Memorial Foundation for Medical and Pharmaceutical Research to F.O. F.O. and M.M. conceived the project. H.K. performed most of the experiments and analyzed the data. T.Y. isolated the bacterial strains and performed some microbial manipulations. Y.A.-T. assisted with experiments and analyses. K.N. made the QUAS-Dark-sh fly line and performed a pilot study. K.Y. R.M. and A.K. performed a pilot study. T.S. performed the CE-MS analysis. T.M. and H.M. analyzed the genome sequences of the bacterial isolates. H.K. and F.O. wrote the initial manuscript. All authors edited and approved the final manuscript. The authors declare no competing interests. Funding Information: We would like to acknowledge Ayame Enomoto, Kaori Saitoh, Keiko Kato, Aki Hori, Takayuki Kuraishi, Yuki Sugiura, and all Miura lab members for technical assistance and critical comments. We thank the Kyoto Stock Center and the Bloomington Drosophila Stock Center for fly stocks. This work was supported by Agency for Medical Research and Development (AMED)-PRIME to F.O. under grant 20gm6010010h0004 , by AMED -CREST to H.M. under grant JP18gm1010006 , and by AMED -Project for Elucidating and Controlling Mechanisms of Aging and Longevity to M.M. under grant JP20gm5010001 . This work was also supported partly by grants from the Japan Society for the Promotion of Science to M.M. under grant 16H06385 , from the Takeda Science Foundation to F.O., and from the Mochida Memorial Foundation for Medical and Pharmaceutical Research to F.O. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jul,
day = "21",
doi = "10.1016/j.celrep.2020.107938",
language = "English",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}