Kosakamoto et al. report that wing necrosis induces dysbiotic expansion of Gluconobacter sp. in the gut, which leads to hyperactivation of innate immunity and mortality in Drosophila. This study highlights an interaction between the host and microbial factors triggering a pathological systemic inflammatory response against local necrosis.
- Immune response
- gut microbiota
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)