Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila

Hina Kosakamoto, Toshitaka Yamauchi, Yoriko Akuzawa-Tokita, Kei Nishimura, Tomoyoshi Soga, Takumi Murakami, Hiroshi Mori, Kyosuke Yamamoto, Ryo Miyazaki, Akiko Koto, Masayuki Miura, Fumiaki Obata

Research output: Contribution to journalArticlepeer-review

Abstract

Kosakamoto et al. report that wing necrosis induces dysbiotic expansion of Gluconobacter sp. in the gut, which leads to hyperactivation of innate immunity and mortality in Drosophila. This study highlights an interaction between the host and microbial factors triggering a pathological systemic inflammatory response against local necrosis.

Original languageEnglish
Article number107938
JournalCell Reports
Volume32
Issue number3
DOIs
Publication statusPublished - 2020 Jul 21

Keywords

  • Drosophila
  • Immune response
  • apoptosis
  • gluconobacter
  • gut microbiota
  • lifespan
  • metabolome
  • necrosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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