Local recurrence after conservative surgery without postoperative radiation for pure tubular carcinoma of the breast: A case report with reference to multifocality of tubular carcinoma

Keiichi Okano, Takashi Fukutomi, Hitoshi Tsuda, Sadako Akashi-Tanaka, Takeshi Nanasawa, Yae Kanai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 49-year-old premenopausal woman with stage I breast carcinoma underwent left quadrantectomy with axillary dissection in 1992. The tumor was 0.7×0.5 cm. Histopathologically, this was a pure tubular carcinoma without lymph node metastasis or lymphatic or vascular invasion. Although the surgical margin was pathologically negative, atypical ductal hyperplasia was present close to the cut margin's edge. Neither adjuvant chemotherapy nor radiotherapy had been given after the operation. Approximately 5 years after the first surgery, she had a local recurrence in the vicinity of the operative wound. There was no clinical evidence of distant metastasis. A salvage mastectomy was performed. Histopathological examination revealed that the second tumor was an invasive ductal carcinoma, histological grade 2, with extensive intraductal component. It was difficult to determine whether this was a true in-breast recurrence or a second primary cancer. Overexpression of p53 and c-erbB-2 was observed in the second tumor. Estrogen receptor and progesterone receptor were both negative. No postoperative chemotherapy was given. Multifocality and atypical ductal hyperplasia were observed in 7 (87.5%) and 6 [75%) of 8 patients, respectively, with tubular carcinoma between 1991 and 1997 at the National Cancer Center Hospital. Coexisting disease associated with tubular carcinoma suggests that radiotherapy may be an important component of breast conservation treatment to prevent local recurrence in this type of tumor.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalBreast Cancer
Volume5
Issue number2
DOIs
Publication statusPublished - 1998 Apr
Externally publishedYes

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Adenocarcinoma
Breast
Radiation
Recurrence
Carcinoma, Intraductal, Noninfiltrating
Neoplasms
Radiotherapy
Lymphatic Metastasis
Cancer Care Facilities
Ductal Carcinoma
Second Primary Neoplasms
Mastectomy
Progesterone Receptors
Adjuvant Chemotherapy
Estrogen Receptors
Blood Vessels
Dissection
Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis

Keywords

  • Breast conservative surgery
  • Multifocality
  • Tubular carcinoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

Local recurrence after conservative surgery without postoperative radiation for pure tubular carcinoma of the breast : A case report with reference to multifocality of tubular carcinoma. / Okano, Keiichi; Fukutomi, Takashi; Tsuda, Hitoshi; Akashi-Tanaka, Sadako; Nanasawa, Takeshi; Kanai, Yae.

In: Breast Cancer, Vol. 5, No. 2, 04.1998, p. 201-204.

Research output: Contribution to journalArticle

Okano, Keiichi ; Fukutomi, Takashi ; Tsuda, Hitoshi ; Akashi-Tanaka, Sadako ; Nanasawa, Takeshi ; Kanai, Yae. / Local recurrence after conservative surgery without postoperative radiation for pure tubular carcinoma of the breast : A case report with reference to multifocality of tubular carcinoma. In: Breast Cancer. 1998 ; Vol. 5, No. 2. pp. 201-204.
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