Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection

Hiroshi Ishii, Shuichi Okada, Haruhiko Nose, Takuji Okusaka, Masayoshi Yoshimori, Tadatoshi Takayama, Tomoo Kosuge, Susumu Yamasaki, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

BACKGROUND. Percutaneous ethanol injection (PEI) therapy is now widely used for small hepatocellular carcinomas (HCC). However, only limited information is available regarding local tumor recurrence after PEI treatment. METHODS. We investigated the relationship of pretreatment clinicopathologic variables (tumor size, tumor cell differentiation and tumor staining) to local recurrence in 170 PEI-treated HCC nodules (measuring 5-39 mm in greatest dimension) in 84 patients. RESULTS. Local recurrence was observed in 17 of 170 PEt-treated nodules. Among these, 13 local recurrences were observed as the first event of progression after PEI. Local recurrence rates at 1, 2, and 4 years were 6.6%, 14.2%, and 14.2%, respectively, and all recurrences were observed within 2 years after PEI. Of the 3 variables investigated, large tumor size (31 mm or larger in greatest dimension) was significantly associated with a higher local recurrence rate. CONCLUSIONS. This study demonstrated that tumor size influences the local efficacy of PEI for small HCC. Therefore, we recommend that a reasonable indication for PEI therapy is HCC lesions measuring less than 30 mm in greatest dimension.

Original languageEnglish
Pages (from-to)1792-1796
Number of pages5
JournalCancer
Volume77
Issue number9
DOIs
Publication statusPublished - 1996 May 1
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
Ethanol
Recurrence
Injections
Neoplasms
Cell Differentiation
Therapeutics
Staining and Labeling

Keywords

  • hepatocellular carcinoma
  • percutaneous ethanol injection
  • recurrence
  • surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ishii, H., Okada, S., Nose, H., Okusaka, T., Yoshimori, M., Takayama, T., ... Hirohashi, S. (1996). Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection. Cancer, 77(9), 1792-1796. https://doi.org/10.1002/(SICI)1097-0142(19960501)77:9<1792::AID-CNCR6>3.0.CO;2-E

Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection. / Ishii, Hiroshi; Okada, Shuichi; Nose, Haruhiko; Okusaka, Takuji; Yoshimori, Masayoshi; Takayama, Tadatoshi; Kosuge, Tomoo; Yamasaki, Susumu; Sakamoto, Michiie; Hirohashi, Setsuo.

In: Cancer, Vol. 77, No. 9, 01.05.1996, p. 1792-1796.

Research output: Contribution to journalArticle

Ishii, H, Okada, S, Nose, H, Okusaka, T, Yoshimori, M, Takayama, T, Kosuge, T, Yamasaki, S, Sakamoto, M & Hirohashi, S 1996, 'Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection', Cancer, vol. 77, no. 9, pp. 1792-1796. https://doi.org/10.1002/(SICI)1097-0142(19960501)77:9<1792::AID-CNCR6>3.0.CO;2-E
Ishii, Hiroshi ; Okada, Shuichi ; Nose, Haruhiko ; Okusaka, Takuji ; Yoshimori, Masayoshi ; Takayama, Tadatoshi ; Kosuge, Tomoo ; Yamasaki, Susumu ; Sakamoto, Michiie ; Hirohashi, Setsuo. / Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection. In: Cancer. 1996 ; Vol. 77, No. 9. pp. 1792-1796.
@article{9cd50302670b4440b2f1d87ae5bc590b,
title = "Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection",
abstract = "BACKGROUND. Percutaneous ethanol injection (PEI) therapy is now widely used for small hepatocellular carcinomas (HCC). However, only limited information is available regarding local tumor recurrence after PEI treatment. METHODS. We investigated the relationship of pretreatment clinicopathologic variables (tumor size, tumor cell differentiation and tumor staining) to local recurrence in 170 PEI-treated HCC nodules (measuring 5-39 mm in greatest dimension) in 84 patients. RESULTS. Local recurrence was observed in 17 of 170 PEt-treated nodules. Among these, 13 local recurrences were observed as the first event of progression after PEI. Local recurrence rates at 1, 2, and 4 years were 6.6{\%}, 14.2{\%}, and 14.2{\%}, respectively, and all recurrences were observed within 2 years after PEI. Of the 3 variables investigated, large tumor size (31 mm or larger in greatest dimension) was significantly associated with a higher local recurrence rate. CONCLUSIONS. This study demonstrated that tumor size influences the local efficacy of PEI for small HCC. Therefore, we recommend that a reasonable indication for PEI therapy is HCC lesions measuring less than 30 mm in greatest dimension.",
keywords = "hepatocellular carcinoma, percutaneous ethanol injection, recurrence, surgery",
author = "Hiroshi Ishii and Shuichi Okada and Haruhiko Nose and Takuji Okusaka and Masayoshi Yoshimori and Tadatoshi Takayama and Tomoo Kosuge and Susumu Yamasaki and Michiie Sakamoto and Setsuo Hirohashi",
year = "1996",
month = "5",
day = "1",
doi = "10.1002/(SICI)1097-0142(19960501)77:9<1792::AID-CNCR6>3.0.CO;2-E",
language = "English",
volume = "77",
pages = "1792--1796",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection

AU - Ishii, Hiroshi

AU - Okada, Shuichi

AU - Nose, Haruhiko

AU - Okusaka, Takuji

AU - Yoshimori, Masayoshi

AU - Takayama, Tadatoshi

AU - Kosuge, Tomoo

AU - Yamasaki, Susumu

AU - Sakamoto, Michiie

AU - Hirohashi, Setsuo

PY - 1996/5/1

Y1 - 1996/5/1

N2 - BACKGROUND. Percutaneous ethanol injection (PEI) therapy is now widely used for small hepatocellular carcinomas (HCC). However, only limited information is available regarding local tumor recurrence after PEI treatment. METHODS. We investigated the relationship of pretreatment clinicopathologic variables (tumor size, tumor cell differentiation and tumor staining) to local recurrence in 170 PEI-treated HCC nodules (measuring 5-39 mm in greatest dimension) in 84 patients. RESULTS. Local recurrence was observed in 17 of 170 PEt-treated nodules. Among these, 13 local recurrences were observed as the first event of progression after PEI. Local recurrence rates at 1, 2, and 4 years were 6.6%, 14.2%, and 14.2%, respectively, and all recurrences were observed within 2 years after PEI. Of the 3 variables investigated, large tumor size (31 mm or larger in greatest dimension) was significantly associated with a higher local recurrence rate. CONCLUSIONS. This study demonstrated that tumor size influences the local efficacy of PEI for small HCC. Therefore, we recommend that a reasonable indication for PEI therapy is HCC lesions measuring less than 30 mm in greatest dimension.

AB - BACKGROUND. Percutaneous ethanol injection (PEI) therapy is now widely used for small hepatocellular carcinomas (HCC). However, only limited information is available regarding local tumor recurrence after PEI treatment. METHODS. We investigated the relationship of pretreatment clinicopathologic variables (tumor size, tumor cell differentiation and tumor staining) to local recurrence in 170 PEI-treated HCC nodules (measuring 5-39 mm in greatest dimension) in 84 patients. RESULTS. Local recurrence was observed in 17 of 170 PEt-treated nodules. Among these, 13 local recurrences were observed as the first event of progression after PEI. Local recurrence rates at 1, 2, and 4 years were 6.6%, 14.2%, and 14.2%, respectively, and all recurrences were observed within 2 years after PEI. Of the 3 variables investigated, large tumor size (31 mm or larger in greatest dimension) was significantly associated with a higher local recurrence rate. CONCLUSIONS. This study demonstrated that tumor size influences the local efficacy of PEI for small HCC. Therefore, we recommend that a reasonable indication for PEI therapy is HCC lesions measuring less than 30 mm in greatest dimension.

KW - hepatocellular carcinoma

KW - percutaneous ethanol injection

KW - recurrence

KW - surgery

UR - http://www.scopus.com/inward/record.url?scp=15844414684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15844414684&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0142(19960501)77:9<1792::AID-CNCR6>3.0.CO;2-E

DO - 10.1002/(SICI)1097-0142(19960501)77:9<1792::AID-CNCR6>3.0.CO;2-E

M3 - Article

C2 - 8646676

AN - SCOPUS:15844414684

VL - 77

SP - 1792

EP - 1796

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -