Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy

H. Kobori, A. Ichihara, Y. Miyashita, M. Hayashi, T. Saruta

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We have reported previously that thyroid hormone activates the circulating and tissue renin-angiotensin systems without involving the sympathetic nervous system, which contributes to cardiac hypertrophy in hyperthyroidism. This study examined whether the circulating or tissue renin- angiotensin system plays the principal role in hyperthyroidism-induced cardiac hypertrophy. The circulating renin-angiotensin system in Sprague- Dawley rats was fixed by chronic angiotensin II infusion (40 ng/min, 28 days) via mini-osmotic pumps. Daily J.p. injection of thyroxine (0 · 1 mg/kg per day, 28 days) was used to mimic hyperthyroidism. Serum free tri- iodothyronine, plasma renin activity, plasma angiotensin II, cardiac renin and cardiac angiotensin II were measured with RIAs. The cardiac expression of renin mRNA was evaluated by semiquantitative reverse transcriptase-polymerase chain reaction. Plasma renin activity and plasma angiotensin II were kept constant in the angiotensin II and angiotensin II+thyroxine groups (0 · 12 ± 0 · 03 and 0 · 15 ±0 · 03 μg/h per liter, 126 ± 5 and 130 ± ng/l respectively) (means ± S.E.M.). Despite stabilization of the circulating renin-angiotensin system, thyroid hormone induced cardiac hypertrophy (5 · 0 ± 0 · 5 vs 3 · 5 ± 0 · 1 mg/g) in conjunction with the increases in cardiac expression of renin mRNA, cardiac renin and cardiac angiotensin II (74 ± 2 vs 48 ± 2%, 6 · 5 ± 0 · 8 vs 3 · 8 ± 0 · 4 ng/h per g, 231 ± 30 vs 149 ± 2 pg/g respectively). These results indicate that the local renin-angiotensin system plays the primary role in the development of hyperthyroidism-induced cardiac hypertrophy.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalJournal of Endocrinology
Volume160
Issue number1
DOIs
Publication statusPublished - 1999

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Cardiomegaly
Hyperthyroidism
Renin-Angiotensin System
Angiotensin II
Renin
Thyroxine
Thyroid Hormones
Messenger RNA
Sympathetic Nervous System
Reverse Transcriptase Polymerase Chain Reaction
Sprague Dawley Rats
Injections
Serum

ASJC Scopus subject areas

  • Endocrinology

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Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy. / Kobori, H.; Ichihara, A.; Miyashita, Y.; Hayashi, M.; Saruta, T.

In: Journal of Endocrinology, Vol. 160, No. 1, 1999, p. 43-47.

Research output: Contribution to journalArticle

Kobori, H, Ichihara, A, Miyashita, Y, Hayashi, M & Saruta, T 1999, 'Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy', Journal of Endocrinology, vol. 160, no. 1, pp. 43-47. https://doi.org/10.1677/joe.0.1600043
Kobori, H. ; Ichihara, A. ; Miyashita, Y. ; Hayashi, M. ; Saruta, T. / Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy. In: Journal of Endocrinology. 1999 ; Vol. 160, No. 1. pp. 43-47.
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